Evidence map›Paper›PMID 30405050›Full record

ArticleNutrients2018

Antonella Orlando, Michele Linsalata, Giusy Bianco, Maria Notarnicola, Benedetta D'Attoma, Maria Principia Scavo, Angela Tafaro, Francesco Russo

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Frontiers in pediatrics · 2021
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Safety Assessment ofMicroorganisms · 2025
    Article
  12. Nutrients · 2025
    Article
  13. Probiotics: a supplement to the gluten-free diet in celiac disease.Gastroenterology and hepatology from bed to bench · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Ability ofInternational journal of molecular sciences · 2023
    Article
  18. Effects of two strains ofFrontiers in microbiology · 2023
    Article
  19. Annals of medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Antonella OrlandoLaboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. antonella.orlando@irccsdebellis.it.
Michele LinsalataLaboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. michele.linsalata@irccsdebellis.it.
Giusy BiancoAnimal Facility, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. giusy.bianco@icloud.com.
Maria NotarnicolaLaboratory of Nutritional Biochemistry, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. maria.notarnicola@irccsdebellis.it.
Benedetta D'AttomaLaboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. benedetta.dattoma@irccsdebellis.it.
Maria Principia ScavoNational Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. maria.scavo@irccsdebellis.it.
Angela TafaroAnimal Facility, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. angela.tafaro@irccsdebellis.it.
Francesco RussoLaboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy. francesco.russo@irccsdebellis.it.ORCID 0000-0003-0538-6072
Gastroenterology Hospital "Saverio de Bellis" · IT

Funding

Italian Ministry of Health 45-24.01.2017
6 · The paper itself

Abstract

Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced paracellular permeability across the intestinal epithelium. The complex system of intercellular junctions, including tight junctions (TJs) and adherens junctions (AJs), seals together the epithelial cells to form a continuous layer. The improvements in barrier integrity have been related to modifications in intercellular junction protein expression. Polyamines (spermidine, spermine, and putrescine) actively participate in the modulation of the AJ expression. Both in vitro and in vivo studies have demonstrated that also probiotics can promote the integrity and the function of the intestinal barrier. On these bases, the present work investigated the protective effects exerted by

Indexed as

Lacticaseibacillus rhamnosusProbioticsAnimalsbeta CateninCadherinsClaudin-1Epithelial CellsGliadinIntestinal DiseasesIntestinal MucosaOccludinPepsin ARatsRats, WistarTight JunctionsTrypsinbeta CateninCadherinsCDH1 protein, ratClaudin-1Cldn1 protein, ratCtnnb1 protein, ratGliadinOccludinOcln protein, ratPepsin ATjp1 protein, ratTrypsinZonula Occludens-1 Proteinadherens junctionsceliac diseasegliadinintestinal permeabilitypolyaminesprobioticstight junctions

Identifiers

PMID30405050
PMCPMC6265991
OpenAlexW2900405036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.