ArticleProceedings. Biological sciences2018
A host immune hormone modifies parasite species interactions and epidemics: insights from a field manipulation.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Higher Temperature and Host Age Alter Infection Outcomes in a Multi-Pathogen System.Ecology and evolution · 2026Article
- Phyllosphere microbial communities are modulated by pathogen coinfection, but not a plant defense hormone.PloS one · 2026Article
- On the Cause and Consequences of Coinfection: A General Mechanistic Framework of Within-Host Parasite Competition.Ecology letters · 2025Review
- Scots Pines With Tolerance to Melampsora pinitorqua and Diplodia sapinea Show Distinct Metabolic Profiles.Plant, cell & environment · 2025Article
- Increased host diversity limits bacterial generalism but may promote microbe-microbe interactions.ISME communications · 2025Article
- Order of arrival and nutrient supply alter outcomes of co-infection with two fungal pathogens.Proceedings. Biological sciences · 2024Article
- Leaf age structures phyllosphere microbial communities in the field and greenhouse.Frontiers in microbiology · 2024Article
- Article
- Altered within- and between-host transmission under coinfection underpin parasite co-occurrence patterns in the wild.Evolutionary ecology · 2023Article
- Indirect interactions among co-infecting parasites and a microbial mutualist impact disease progression.Proceedings. Biological sciences · 2021Article
- The timing and asymmetry of plant-pathogen-insect interactions.Proceedings. Biological sciences · 2020Article
- Towards a mechanistic understanding of competence: a missing link in diversity-disease research.Parasitology · 2020Article
- Within-host priority effects and epidemic timing determine outbreak severity in co-infected populations.Proceedings. Biological sciences · 2020Article
- A host immune hormone modifies parasite species interactions and epidemics: insights from a field manipulation.Proceedings. Biological sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasite epidemics can depend on priority effects, and parasite priority effects can result from the host immune response to prior infection. Yet we lack experimental evidence that such immune-mediated priority effects influence epidemics. To address this research gap, we manipulated key host immune hormones, then measured the consequences for within-host parasite interactions, and ultimately parasite epidemics in the field. Specifically, we applied plant immune-signalling hormones to sentinel plants, embedded into a wild host population, and tracked foliar infections caused by two common fungal parasites. Within-host individuals, priority effects were altered by the immune-signalling hormone, salicylic acid (SA). Scaling up from within-host interactions, hosts treated with SA experienced a lower prevalence of a less aggressive parasite, increased burden of infection by a more aggressive parasite, and experienced fewer co-infections. Together, these results indicate that by altering within-host priority effects, host immune hormones can drive parasite epidemics. This study therefore experimentally links host immune hormones to within-host priority effects and parasite epidemics, advancing a more mechanistic understanding of how interactions among parasites alter their epidemics.
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