ArticleProceedings. Biological sciences2018
An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Characterizing the detectable and invisible fractions of genomic loci under balancing selection.Molecular biology and evolution · 2026Article
- Developmental speed and chronological time exert opposing effects on the spontaneous mutation rate inEvolution letters · 2026Article
- Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.Genetics · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Article
- Quantitative genetics of trauma induced mortality inbioRxiv : the preprint server for biology · 2025Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers.Evolutionary applications · 2025Article
- Sex-specific viability effects of mutations in Drosophila melanogaster.Evolution; international journal of organic evolution · 2024Article
- Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast.Genome biology and evolution · 2023Article
- Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation.Evolutionary ecology · 2022Article
- Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantitative and population genetic insights.Genetics · 2021Article
- Selection in males purges the mutation load on female fitness.Evolution letters · 2021Article
- Is the X chromosome a hot spot for sexually antagonistic polymorphisms? Biases in current empirical tests of classical theory.Proceedings. Biological sciences · 2020Article
- Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated.Development (Cambridge, England) · 2020Article
- Stability of petal color polymorphism: the significance of anthocyanin accumulation in photosynthetic tissues.BMC plant biology · 2019Article
- No evidence of positive assortative mating for genetic quality in fruit flies.Proceedings. Biological sciences · 2019Article
- Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes inProceedings of the National Academy of Sciences of the United States of America · 2019Article
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2 authors.
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Abstract
Despite decades of research, the factors that maintain genetic variation for fitness are poorly understood. It is unclear what fraction of the variance in a typical fitness component can be explained by mutation-selection balance (MSB) and whether fitness components differ in this respect. In theory, the level of standing variance in fitness due to MSB can be predicted using the rate of fitness decline under mutation accumulation, and this prediction can be directly compared to the standing variance observed. This approach allows for controlled statistical tests of the sufficiency of the MSB model, and could be used to identify traits or populations where genetic variance is maintained by other factors. For example, some traits may be influenced by sexually antagonistic balancing selection, resulting in an excess of standing variance beyond that generated by deleterious mutations. We describe the underlying theory and use it to test the MSB model for three traits in
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