ArticleOpen biology2018
Phosphorylation of Parkin at serine 65 is essential for its activation
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In one paragraph
Article in Open biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Emerging roles of ATG7 in human health and disease.EMBO molecular medicine · 2021Pooled it
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Proteomics reveal PTEN as a critical mediator of sustained mitochondrial dysfunction during chronic spinal cord injury.Experimental neurology · 2026Article
- PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.EMBO reports · 2026Article
- Species-dependent activities of the PINK1-parkin axis.Translational neurodegeneration · 2026Review
- The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.Cell death and differentiation · 2026Article
- Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026Review
- DYRK1A and Parkinson's disease, facts and hypotheses.Neurobiology of disease · 2026Review
- Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease.Biomedicines · 2026Review
- Tissue-specific mutation of pink-1 jointly induces intestinal dysfunction and contributes to dopaminergic neuron degeneration.NPJ Parkinson's disease · 2026Article
- Dynamic structural profiling of PINK1 mutations (T313M and L347P) reveals a vital molecular perturbation namely phospho-Serine 65 ubiquitin recognition point in mitophagy mediated autosomal recessive Parkinson's disease (ARPD).Frontiers in molecular neuroscience · 2026Article
- Rethinking PINK1/Parkin-mediated mitophagy in Parkinson's disease: functional continuity and activation-clearance uncoupling.Frontiers in aging neuroscience · 2026Review
- Absence of Parkin Results in Atrophy of Oxidative Myofibers and Modulation of AKT and MURF1 Signaling in Middle-Aged Male Mice.Acta physiologica (Oxford, England) · 2025Article
- Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling.Science advances · 2025Article
- Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Changes to the Autophagy-Related Muscle Proteome Following Short-Term Treatment with Ectoine in the Duchenne Muscular Dystrophy Mouse Model mdx.International journal of molecular sciences · 2025Article
- Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1.International journal of biological sciences · 2025Article
- Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging.The EMBO journal · 2024Article
- Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.The Journal of clinical investigation · 2024Article
- Ubiquitin system mutations in neurological diseases.Trends in biochemical sciences · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 5 institutions in 4 countries.
Thomas G McWilliamsMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK thomas.mcwilliams@helsinki.fi.
Erica BariniMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Risto Pohjolan-PirhonenResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Simon P BrooksThe Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK.
François SinghMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Sophie BurelMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Kristin BalkMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Atul KumarMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Lambert Montava-GarrigaMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Alan R PrescottDundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Sidi Mohamed HassounCNRS, Inserm, Paris, France.
François Mouton-LigerCNRS, Inserm, Paris, France.
Graeme BallDundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Rachel HillsThe Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK.
Axel KnebelMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Ayse UlusoyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Donato A Di MonteGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Jevgenia TamjarMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Odetta AnticoMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Kyle FearsThe Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK.
Laura SmithThe Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK.
Riccardo BrambillaNeuroscience & Mental Health Institute, Neuroscience Division, School of Biosciences, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK.
Eino PalinResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Miko ValoriResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Johanna Eerola-RautioResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Pentti TienariResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Olga CortiCNRS, Inserm, Paris, France.
Stephen B DunnettThe Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK.
Ian G GanleyMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Anu SuomalainenResearch Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.
Miratul M K MuqitMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK m.muqit@dundee.ac.uk.ORCID 0000-0001-9733-2404
University of Dundee · GBUniversity of Helsinki · FICardiff University · GBCentre National de la Recherche Scientifique · FRGerman Center for Neurodegenerative Diseases · DE
Funding
Medical Research Council MC_UU_00018/2Medical Research Council MC_UU_12016/4Medical Research Council MR/K015869/1Wellcome Trust 210753/Z/18/Z
Abstract
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and
Indexed as
MitophagyUbiquitin-Protein LigasesAnimalsHumansMiceMice, TransgenicMitochondriaParkinson DiseasePhosphorylationProtein KinasesPTEN-Induced Putative KinaseSerineparkin proteinProtein KinasesPTEN-Induced Putative KinaseSerineUbiquitin-Protein LigasesmitochondriamitophagyneurodegenerationParkin, Parkinson's diseasePINK1
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.