Evidence map›Paper›PMID 30404812›Full record

ArticleBlood2019

Resolution of sickle cell disease-associated inflammation and tissue damage with 17

Alessandro Matte, Antonio Recchiuti, Enrica Federti, Bérengère Koehl, Thomas Mintz, Wassim El Nemer, Pierre-Louis Tharaux, Valentine Brousse, Immacolata Andolfo, Alessia Lamolinara and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 65 citations in OpenAlex.

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  20. Targeting Angiogenesis via Resolution of Inflammation.Cold Spring Harbor perspectives in medicine · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Alessandro MatteDepartment of Medicine, University of Verona, Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Antonio RecchiutiDepartment of Medical, Oral, and Biotechnology Science and Center of Excellence on Aging and Translational Medicine, "G. d'Annunzio" University of Chieti, Chieti, Italy.ORCID 0000-0002-1409-5261
Enrica FedertiDepartment of Medicine, University of Verona, Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Bérengère KoehlLaboratoire d'Excellence GR-Ex, Unité Biologie Intégrée du Globule Rouge, NTS, INSERM, Paris Diderot University, Sorbonne Paris Cité University, Paris, France.
Thomas MintzParis Cardiovascular Research Centre, INSERM and Paris Descartes University, Paris, France.
Wassim El NemerLaboratoire d'Excellence GR-Ex, Unité Biologie Intégrée du Globule Rouge, NTS, INSERM, Paris Diderot University, Sorbonne Paris Cité University, Paris, France.
Pierre-Louis TharauxParis Cardiovascular Research Centre, INSERM and Paris Descartes University, Paris, France.ORCID 0000-0002-6062-5905
Valentine BrousseAssistance Publique Hopitaux de Paris, Necker Hospital, Paris, France.
Immacolata AndolfoDepartment of Molecular Medicine and Medical Biotechnologies, Federico II University, and CEINGE, Biotecnologie Avanzate, Naples, Italy.ORCID 0000-0003-0493-812X
Alessia LamolinaraCenter of Excellence on Aging and Translational Medicine, Department of Medicine and Aging Science, "G. D'Annunzio" University of Chieti, Chieti, Italy.
Olga WeinbergDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Angela SicilianoDepartment of Medicine, University of Verona, Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Paul C NorrisCenter of Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and.ORCID 0000-0003-2512-0829
Ian R RileyCenter of Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and.
Achille IolasconDepartment of Molecular Medicine and Medical Biotechnologies, Federico II University, and CEINGE, Biotecnologie Avanzate, Naples, Italy.ORCID 0000-0002-9558-0356
Charles N SerhanCenter of Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; and.ORCID 0000-0003-4627-8545
Carlo BrugnaraDepartment of Laboratory Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Lucia De FranceschiDepartment of Medicine, University of Verona, Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.ORCID 0000-0001-7093-777X
Inserm · FRUniversity of Verona · ITBrigham and Women's Hospital · USBoston Children's Hospital · USCeinge Biotecnologie Avanzate (Italy) · ITUniversity of Chieti-Pescara · ITAssistance Publique – Hôpitaux de Paris · FR

Funding

BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
NIGMS NIH HHS R01 GM038765
6 · The paper itself

Abstract

Resolvins (Rvs), endogenous lipid mediators, play a key role in the resolution of inflammation. Sickle cell disease (SCD), a genetic disorder of hemoglobin, is characterized by inflammatory and vaso-occlusive pathologies. We document altered proresolving events following hypoxia/reperfusion in humanized SCD mice. We demonstrate novel protective actions of 17

Indexed as

Anemia, Sickle CellAnimalsAnti-Inflammatory Agents, Non-SteroidalCytokinesDocosahexaenoic AcidsHumansKidney DiseasesMiceNeutrophilsPneumoniaAnti-Inflammatory Agents, Non-SteroidalCytokinesDocosahexaenoic Acidsresolvin D1

Identifiers

PMID30404812
PMCPMC6337877
OpenAlexW2900408930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.