Evidence map›Paper›PMID 30404566›Full record

ArticleCancer biology & therapy2019

STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway.

Zhe Liu, Hong Li, Sumeng Fan, Hui Lin, Wenwei Lian

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  3. Mechanistic insights into the lncRNA-Notch signaling axis in tumors.Frontiers in cell and developmental biology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhe Liua The Affiliated Stomatological Hospital of Nanchang University , The Key Laboratory of Oral Biomedicine , Nanchang , Jiangxi Province , China.
Hong Lia The Affiliated Stomatological Hospital of Nanchang University , The Key Laboratory of Oral Biomedicine , Nanchang , Jiangxi Province , China.
Sumeng Fana The Affiliated Stomatological Hospital of Nanchang University , The Key Laboratory of Oral Biomedicine , Nanchang , Jiangxi Province , China.
Hui Linb Department of Pathophysiology, Schools of Basic Sciences Nanchang University Medical College , Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology , Nanchang, Jiangxi Province , China.
Wenwei Liana The Affiliated Stomatological Hospital of Nanchang University , The Key Laboratory of Oral Biomedicine , Nanchang , Jiangxi Province , China.
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are a group of biomarkers which can regulate the biological processes of various human cancers. LncRNA HNF1A-AS1 has been reported in human cancers for its oncogenic role. This study focused on the biological function and molecular mechanism of HNF1A-AS1 in oral squamous cell carcinoma (OSCC). The high expression of HNF1A-AS1 was examined in OSCC tissues and cell lines. Kaplan Meier method revealed that high expression of HNF1A-AS1 predicted poor prognosis for patients with OSCC. Results of loss-of-function assays demonstrated that silenced HNF1A-AS1 inhibited the proliferation, migration and epithelial-mesenchymal transition (EMT) of OSCC cells. Mechanically, HNF1A-AS1 was positively regulated by the transcription factor STAT3. Recently, Notch signaling pathway has been reported in human malignancies. In this study, we analyzed the correlation between HNF1A-AS1 and Notch signaling pathway. It was uncovered that the expression of Notch1 and Hes1 (the core factors of Notch signaling pathway) was negatively regulated by HNF1A-AS1 knockdown. Rescue assays further demonstrated the positive regulatory effects of HNF1A-AS1 on Notch signaling pathway in OSCC. In conclusion, upregulation of HNF1A-SA1 induced by transcription factor STAT3 promotes OSCC progression by activating Notch signaling pathway.

Indexed as

Gene Expression Regulation, NeoplasticApoptosisBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesCell MovementCell ProliferationDisease ProgressionEpithelial-Mesenchymal TransitionFemaleFollow-Up StudiesHumansMaleMiddle AgedMouth NeoplasmsPrognosisBiomarkers, Tumorlong non-coding RNA HNF1A-AS1, humanNOTCH1 protein, humanReceptor, Notch1RNA, Long NoncodingSTAT3 protein, humanSTAT3 Transcription FactorHNF1A-AS1migrationNotch signaling pathwayOSCCproliferation

Identifiers

PMID30404566
PMCPMC6422516
OpenAlexW2900092194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.