Evidence map›Paper›PMID 30404372›Full record

ArticleMicromachines2016

Microfluidic Paper-Based Sample Concentration Using Ion Concentration Polarization with Smartphone Detection.

Xue Li, Yanan Niu, Yunyi Chen, Di Wu, Long Yi, Xianbo Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xue LiInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. 2015210307@grad.buct.edu.cn.
Yanan NiuInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. 2015210306@grad.buct.edu.cn.
Yunyi ChenInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. 2015200729@mail.buct.edu.cn.
Di WuInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. wudi@mail.buct.edu.cn.
Long YiInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. yilong@mail.buct.edu.cn.
Xianbo QiuInstitute of Microfluidic Chip Development in Biomedical Engineering, State Key Laboratory of Organic-Inorganic Composites, College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. xbqiu@mail.buct.edu.cn.

Funding

National Natural Science Foundation of China 81371711
6 · The paper itself

Abstract

A simple method for microfluidic paper-based sample concentration using ion concentration polarization (ICP) with smartphone detection is developed. The concise and low-cost microfluidic paper-based ICP analytical device, which consists of a black backing layer, a nitrocellulose membrane, and two absorbent pads, is fabricated with the simple lamination method which is widely used for lateral flow strips. Sample concentration on the nitrocellulose membrane is monitored in real time by a smartphone whose camera is used to collect the fluorescence images from the ICP device. A custom image processing algorithm running on the smartphone is used to track the concentrated sample and obtain its fluorescence signal intensity for quantitative analysis. Two different methods for Nafion coating are evaluated and their performances are compared. The characteristics of the ICP analytical device especially with intentionally adjusted physical properties are fully evaluated to optimize its performance as well as to extend its potential applications. Experimental results show that significant concentration enhancement with fluorescence dye sample is obtained with the developed ICP device when a fast depletion of fluorescent dye is observed. The platform based on the simply laminated ICP device with smartphone detection is desired for point-of-care testing in settings with poor resources.

Indexed as

ion concentration polarization (ICP)Nafion coatingpaper-based microfluidicspoint-of-care testsample concentrationsmartphone

Identifiers

PMID30404372
PMCPMC6189865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.