Evidence map›Paper›PMID 30404356›Full record

ArticleMicromachines2016

Continuously Operating Biosensor and Its Integration into a Hermetically Sealed Medical Implant.

Mario Birkholz, Paul Glogener, Franziska Glös, Thomas Basmer, Lorenz Theuer

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mario BirkholzIHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany. birkholz@ihp-microelectronics.com.ORCID 0000-0002-5818-7379
Paul GlogenerIHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany. glogener@fh-aachen.de.
Franziska GlösIHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany. franziska.gloes@th-wildau.de.
Thomas BasmerIHP, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany. thomas.basmer@hsae.eu.
Lorenz TheuerDepartment of Biotechnology, Technical University Berlin, ACK24, Ackerstr. 76, 13355 Berlin, Germany. Lorenz.Theuer@acreo.se.
Institut für Solartechnologien (Germany) · DETechnische Universität Berlin · DE

Funding

Bundesministerium für Bildung und Forschung 16SV3934
6 · The paper itself

Abstract

An integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a fully embedded biomedical microelectromechanical systems (BioMEMS) prepared in 0.25-µm complementary metal⁻oxide⁻semiconductor (CMOS)/BiCMOS technology. Communication with a base station is established in the 402⁻405 MHz band used for medical implant communication services (MICS). The implant shall operate within the interstitial tissue, and the hermetical sealing of the electronic system against interaction with the body fluid is established using titanium housing. Only the sensor chip and the antenna are encapsulated in an epoxy header closely connected to the metallic housing. The study demonstrates that biosensor implants for the sensing of low-molecular-weight metabolites in the interstitial may successfully rely on components already established in cardiovascular implantology.

Indexed as

affinity assayBioMEMSbiosensorcontinuous glucose monitoringmedical implantmetallic housingsterilizationtitanium

Identifiers

PMID30404356
PMCPMC6190112
OpenAlexW2530547452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.