ReviewMicromachines2016
Neural Probes for Chronic Applications.
Review in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Fabrication of High-Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Friend, Not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Friend, not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.bioRxiv : the preprint server for biology · 2026Article
- A Translational Platform for Polyimide Neural Interfaces: Polyimide Synthesis and in Vivo Evaluation in Epileptic Mice.IEEE access : practical innovations, open solutions · 2026Article
- Mechanical Behavior Analysis of Neural Electrode Arrays Implantation in Brain Tissue.Micromachines · 2025Article
- Recent Advances in Flexible Sensors for Neural Interfaces: Multimodal Sensing, Signal Integration, and Closed-Loop Feedback.Biosensors · 2025Review
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Multimodal integrated flexible neural probe forRSC advances · 2024Article
- Proof of Concept for Sustainable Manufacturing of Neural Electrode Array for In Vivo Recording.Biosensors · 2023Article
- Recent developments in multifunctional neural probes for simultaneous neural recording and modulation.Microsystems & nanoengineering · 2023Review
- A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- A comparison of insertion methods for surgical placement of penetrating neural interfaces.Journal of neural engineering · 2021Review
- Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution.Frontiers in medical technology · 2021Review
- Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants.Frontiers in neuroscience · 2021Article
- Chronic, Multi-Site Recordings Supported by Two Low-Cost, Stationary Probe Designs Optimized to Capture Either Single Unit or Local Field Potential Activity in Behaving Rats.Frontiers in psychiatry · 2021Article
- Microtopographical patterns promote different responses in fibroblasts and Schwann cells: A possible feature for neural implants.Journal of biomedical materials research. Part A · 2021Article
- A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery.Microsystems & nanoengineering · 2021Article
- Evaluation of Durability of Transparent Graphene Electrodes Fabricated on Different Flexible Substrates for Chronic In Vivo Experiments.IEEE transactions on bio-medical engineering · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Developed over approximately half a century, neural probe technology is now a mature technology in terms of its fabrication technology and serves as a practical alternative to the traditional microwires for extracellular recording. Through extensive exploration of fabrication methods, structural shapes, materials, and stimulation functionalities, neural probes are now denser, more functional and reliable. Thus, applications of neural probes are not limited to extracellular recording, brain-machine interface, and deep brain stimulation, but also include a wide range of new applications such as brain mapping, restoration of neuronal functions, and investigation of brain disorders. However, the biggest limitation of the current neural probe technology is chronic reliability; neural probes that record with high fidelity in acute settings often fail to function reliably in chronic settings. While chronic viability is imperative for both clinical uses and animal experiments, achieving one is a major technological challenge due to the chronic foreign body response to the implant. Thus, this review aims to outline the factors that potentially affect chronic recording in chronological order of implantation, summarize the methods proposed to minimize each factor, and provide a performance comparison of the neural probes developed for chronic applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.