ArticleMicromachines2016
An On-Chip RBC Deformability Checker Significantly Improves Velocity-Deformation Correlation.
Article in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- On-Chip Evaluation of Red Blood Cell Deformability Through Transit Velocity Index in Hematological Diseases.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Red Blood Cell Deformability in Microfluidic Constrictions Under Flow and Wall Contact.Micromachines · 2026Article
- An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells.Scientific reports · 2025Article
- Measuring cell deformation by microfluidics.Frontiers in bioengineering and biotechnology · 2023Review
- Deformation of an Encapsulated Leukemia HL60 Cell through Sudden Contractions of a Microfluidic Channel.Micromachines · 2021Article
- Neural Network for Enhancing Microscopic Resolution Based on Images from Scanning Electron Microscope.Sensors (Basel, Switzerland) · 2021Article
- A New 3D Cultured Liver Chip and Real-Time Monitoring System Based on Microfluidic Technology.Micromachines · 2020Article
- Rotational manipulation of a microscopic object inside a microfluidic channel.Biomicrofluidics · 2020Article
- Applications of machine learning for simulations of red blood cells in microfluidic devices.BMC bioinformatics · 2020Article
- Deformation of a Red Blood Cell in a Narrow Rectangular Microchannel.Micromachines · 2019Article
- Assessment of the Deformability and Velocity of Healthy and Artificially Impaired Red Blood Cells in Narrow Polydimethylsiloxane (PDMS) Microchannels.Micromachines · 2018Article
- Multidisciplinary Role of Microfluidics for Biomedical and Diagnostic Applications: Biomedical Microfluidic Devices.Micromachines · 2017Article
- Temporal Transition of Mechanical Characteristics of HUVEC/MSC Spheroids Using a Microfluidic Chip with Force Sensor Probes.Micromachines · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
An on-chip deformability checker is proposed to improve the velocity⁻deformation correlation for red blood cell (RBC) evaluation. RBC deformability has been found related to human diseases, and can be evaluated based on RBC velocity through a microfluidic constriction as in conventional approaches. The correlation between transit velocity and amount of deformation provides statistical information of RBC deformability. However, such correlations are usually only moderate, or even weak, in practical evaluations due to limited range of RBC deformation. To solve this issue, we implemented three constrictions of different width in the proposed checker, so that three different deformation regions can be applied to RBCs. By considering cell responses from the three regions as a whole, we practically extend the range of cell deformation in the evaluation, and could resolve the issue about the limited range of RBC deformation. RBCs from five volunteer subjects were tested using the proposed checker. The results show that the correlation between cell deformation and transit velocity is significantly improved by the proposed deformability checker. The absolute values of the correlation coefficients are increased from an average of 0.54 to 0.92. The effects of cell size, shape and orientation to the evaluation are discussed according to the experimental results. The proposed checker is expected to be useful for RBC evaluation in medical practices.
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Registered trials
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