Evidence map›Paper›PMID 30404325›Full record

ArticleMicromachines2016

Enhanced Throughput for Electrokinetic Manipulation of Particles and Cells in a Stacked Microfluidic Device.

Lin Zhu, Saurin H Patel, Mark Johnson, Akshay Kale, Yash Raval, Tzuen-Rong Tzeng, Xiangchun Xuan

Abstract read
In one paragraph

Article in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin ZhuSchool of Engineering, Anhui Agricultural University, Hefei 230036, China. zl009@mail.ustc.edu.cn.
Saurin H PatelDepartment of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, USA. saurinp@g.clemson.edu.ORCID 0000-0003-3650-1790
Mark JohnsonDepartment of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, USA. mhjohns@g.clemson.edu.
Akshay KaleDepartment of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, USA. akale@g.clemson.edu.
Yash RavalDepartment of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USA. yraval@g.clemson.edu.
Tzuen-Rong TzengDepartment of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USA. TZUENRT@clemson.edu.
Xiangchun XuanDepartment of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, USA. xcxuan@clemson.edu.ORCID 0000-0003-0158-4186

Funding

NSF CBET-0853873NSFC 51575003
6 · The paper itself

Abstract

Electrokinetic manipulation refers to the control of particle and cell motions using an electric field. It is an efficient technique for microfluidic applications with the ease of operation and integration. It, however, suffers from an intrinsic drawback of low throughput due to the linear dependence of the typically very low fluid permittivity. We demonstrate in this work a significantly enhanced throughput for electrokinetic manipulation of particles and cells by the use of multiple parallel microchannels in a two-layer stacked microfluidic device. The fabrication of this device is simple without the need of a precise alignment of the two layers. The number of layers and the number of microchannels in each layer can thus be further increased for a potentially high throughput electrokinetic particle and cell manipulations.

Indexed as

dielectrophoresisparallel operationparticle concentrationparticle separationreservoir

Identifiers

PMID30404325
PMCPMC6190188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.