ArticleMicromachines2016
Towards an Implantable, Low Flow Micropump That Uses No Power in the Blocked-Flow State.
Article in Micromachines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Microfluidic technologies for wearable and implantable biomedical devices.Lab on a chip · 2025Review
- A review of peristaltic micropumps.Sensors and actuators. A, Physical · 2021Article
- In-Vivo Microsystems: A Review.Sensors (Basel, Switzerland) · 2020Review
- A 3D-Printed Modular Microreservoir for Drug Delivery.Micromachines · 2020Article
- Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications.Frontiers in bioengineering and biotechnology · 2020Review
- A nanoliter resolution implantable micropump for murine inner ear drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Animal model studies yield translational solutions for cochlear drug delivery.Hearing research · 2018Review
- Biocompatible Magnetic Nanocomposite Microcapsules as Microfluidic One-way Diffusion Blocking Valves with Ultra-low Opening Pressure.Materials & design · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Low flow rate micropumps play an increasingly important role in drug therapy research. Infusions to small biological structures and lab-on-a-chip applications require ultra-low flow rates and will benefit from the ability to expend no power in the blocked-flow state. Here we present a planar micropump based on gallium phase-change actuation that leverages expansion during solidification to occlude the flow channel in the off-power state. The presented four chamber peristaltic micropump was fabricated with a combination of Micro Electro Mechanical System (MEMS) techniques and additive manufacturing direct write technologies. The device is 7 mm × 13 mm × 1 mm (<100 mm³) with the flow channel and exterior coated with biocompatible Parylene-C, critical for implantable applications. Controllable pump rates from 18 to 104 nL/min were demonstrated, with 11.1 ± 0.35 nL pumped per actuation at an efficiency of 11 mJ/nL. The normally-closed state of the gallium actuator prevents flow and diffusion between the pump and the biological system or lab-on-a-chip, without consuming power. This is especially important for implanted applications with periodic drug delivery regimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.