Evidence map›Paper›PMID 30404033›Full record

Trial reportAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2019

Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies.

Amanda J Stranks, Samantha C Minnicozzi, Samuel J Miller, Oliver T Burton, Stephanie L Logsdon, Jonathan M Spergel, Kari C Nadeau, Jacqueline A Pongracic, Dale T Umetsu, Rima Rachid and 3 more

Abstract readLetterMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Oral Immunotherapy for Children with Cow's Milk Allergy.Pathogens (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Mechanisms of oral immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda J StranksDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Currently: University of Cambridge, Cambridge, United Kingdom.
Samantha C MinnicozziDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Samuel J MillerDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Oliver T BurtonDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Stephanie L LogsdonDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Currently: Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio.
Jonathan M SpergelDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kari C NadeauDepartment of Medicine, Stanford University, Palo Alto, California.
Jacqueline A PongracicDepartment of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Dale T UmetsuGenentech, South San Francisco, California.
Rima RachidDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Andrew J MacGinnitieDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Lynda C SchneiderDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Hans C OettgenDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Electronic address: Hans.Oettgen@childrens.harvard.edu.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Mast cell regulation of Th2 induction and tolerance breakdown in food allergyR01AI119918 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI OETTGEN, HANS C · 2015 to 2025
$5.6M
IgG and Fc gamma receptor regulation of food allergy and oral toleranceK01DK106303 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BURTON, OLIVER TEAL · 2015 to 2016
$256k
NCATS NIH HHS UL1 TR001422NIAID NIH HHS R01 AI119918NIAID NIH HHS T32 AI007512NIDDK NIH HHS K01 DK106303
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Desensitization, ImmunologicAntibodies, Anti-IdiotypicHumansImmunoglobulin GOmalizumabPeanut HypersensitivityAntibodies, Anti-Idiotypicanti-IgE antibodiesImmunoglobulin GOmalizumab

Identifiers

PMID30404033
PMCPMC6360101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.