Evidence map›Paper›PMID 30403991›Full record

ArticleStructure (London, England : 1993)2018

Elusive Conformational Dynamics of PPARγ Inactivation Tied Down by Chemical Cross-Linking.

Jared P Mohr, James E Bruce

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jared P MohrDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, USA.
James E BruceDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, USA. Electronic address: jimbruce@uw.edu.
University of Washington · US

Funding

Quantitation of protein interactions in cancer cellsR01GM086688 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD · 2009 to 2019
$4.2M
Instrumentation Development: MS Array for Quantitative ProteomicsR01GM097112 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD · 2011 to 2020
$2.9M
NIGMS NIH HHS R01 GM086688NIGMS NIH HHS R01 GM097112
6 · The paper itself

Abstract

In this issue of Structure, Zheng et al. (2018) have described the dynamics of PPARγ in complex with a non-agonist by exploring its solution-phase conformational landscape through chemical cross-linking in combination with a multitude of different treatment conditions, including their new synthetic anti-diabetic non-agonist, revealing the physical mechanism of PPARγ inactivation.

Indexed as

PPAR gammaThiazolidinedionesLigandsMass SpectrometryMolecular ConformationLigandsPPAR gammaThiazolidinediones

Identifiers

PMID30403991
PMCPMC6516750
OpenAlexW2899818564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.