Evidence map›Paper›PMID 30403772›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study.

Thomas Yates, Charlotte L Edwardson, Carlos Celis-Morales, Stuart J H Biddle, Danielle Bodicoat, Melanie J Davies, Dale Esliger, Joe Henson, Aadil Kazi, Kamesh Khunti and 6 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02453204 (STAND UP - Sedentary Behaviour in Older Adults), which is not on this map. Cited by 48 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 8 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02453204 nacompletednot on this map

STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm Work Package 3: Investigating the Effect of Sedentary Time, Reduced Sedentary Time and Increased Light-intensity Physical Activity on Metabolic and Psychological Health in Older Adults

TypeinterventionalSponsorUniversity of LeicesterRan2015 to 2017Enrolled76ConditionsOlder AdultsArmsSitting, Standing, Walking
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 8 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Thomas YatesDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Charlotte L EdwardsonDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Carlos Celis-MoralesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Australia.
Stuart J H BiddleInstitute for Resilient Regions, University of Southern Queensland, Springfield Central, Australia.
Danielle BodicoatDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Melanie J DaviesDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Dale EsligerSchool of Sport, Exercise, and Health Sciences, Loughborough University, Birmingham.
Joe HensonDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Aadil KaziLeicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Diabetes Frail Ltd and University of Aston, Birmingham.
Kamesh KhuntiDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Australia.
Alan J SinclairFoundation for Diabetes Research in Older People, Diabetes Frail Ltd and University of Aston, Birmingham.
Alex RowlandsDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Latha VelayudhanInstitute of Psychiatry, Psychology and Neurosciences, King's College London.
Francesco ZaccardiDiabetes Research Centre, College of Life Sciences, University of Leicester, Australia.
Jason M R GillInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Australia.
Diabetes Foundation · INLoughborough University · GBNIHR Applied Research Collaboration Greater ManchesterUniversity Hospitals of Leicester NHS Trust · GBUniversity of Leicester · GBUniversity of Southern Queensland · AU

Funding

Department of HealthMedical Research Council MR/K025090/1
6 · The paper itself

Abstract

backgroundProlonged sitting is common in older adults and is associated with insulin resistance and poor cardiometabolic health. We investigate whether breaking prolonged sitting with regular short bouts of standing or light walking improves postprandial metabolism in older white European and South Asian adults and whether effects are modified by ethnic group.

methodsThirty South Asian (15 women) and 30 white European (14 women) older adults (aged 65-79 years) undertook three experimental conditions in random order. (a) Prolonged sitting: continuous sitting during an observation period if 7.5 hours consuming two standardized mixed meals. (b) Standing breaks: sitting interrupted with 5 minutes of standing every 30 minutes (accumulating 60 minutes of standing over the observation period). (c) Walking breaks: sitting interrupted with 5 minutes of self-paced light walking every 30 minutes (accumulating 60 minutes of walking). Blood samples (glucose, insulin, triglycerides) and blood pressure were sampled regularly throughout each condition.

resultsCompared with prolonged sitting, walking breaks lowered postprandial insulin by 16.3 mU/L, (95% CI: 19.7, 22.0) with greater reductions (p = .029) seen in South Asians (22.4 mU/L; 12.4, 32.4) than white Europeans (10.3 mU/L; 5.9, 14.7). Glucose (0.3 mmol/L; 0.1, 0.5) and blood pressure (4 mm Hg; 2, 6), but not triglycerides, were lower with walking breaks, with no ethnic differences. Standing breaks did not improve any outcome.

conclusionsBreaking prolonged sitting with short bouts of light walking, but not standing, resulted in clinically meaningful improvements in markers of metabolic health in older adults, with South Asians gaining a greater reduction in postprandial insulin.

trial registrationNCT02453204.

Indexed as

Asian PeopleWhite PeopleAgedAustraliaBlood GlucoseBlood PressureCardiovascular DiseasesFemaleHumansIncidenceInsulinInsulin ResistanceMalePostprandial PeriodPostureSedentary BehaviorBlood GlucoseInsulinTriglyceridesEthnicityPhysical activitySedentary behaviorWalking

Identifiers

PMID30403772
PMCPMC6909896
OpenAlexW2898709259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.