Evidence map›Paper›PMID 30403401›Full record

ArticleImmunology2019

HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis.

Bhawana Singh, Michaela Fakiola, Medhavi Sudarshan, Joyce Oommen, Siddharth Sankar Singh, Shyam Sundar, Jenefer M Blackwell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Spatial and Temporal Variability of Visceral Leishmaniasis in Colombia, 2007 to 2018.The American journal of tropical medicine and hygiene · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Bhawana SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Michaela FakiolaDepartment of Pathology, The University of Cambridge, Cambridge, UK.
Medhavi SudarshanDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Joyce OommenTelethon Kids Institute, The University of Western Australia, West Perth, WA, Australia.
Siddharth Sankar SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Shyam SundarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Jenefer M BlackwellDepartment of Pathology, The University of Cambridge, Cambridge, UK.ORCID 0000-0002-0784-7277
Institute of Medical Sciences · INThe Kids Research Institute Australia · AUUniversity of Cambridge · GB

Funding

Visceral Leishmaniasis in Bihar State, IndiaP50AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2007 to 2016
$6.4M
Visceral Leishmaniasis in Bihar State, IndiaU19AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2017 to 2021
$2.8M
NIAID NIH HHS P50 AI074321NIAID NIH HHS U19 AI074321NIH HHS 1P50AI074321-01
6 · The paper itself

Abstract

Genetic variation at HLA-DRB1 is a risk factor for visceral leishmaniasis (VL) caused by Leishmania donovani. The single nucleotide polymorphism rs9271252 upstream of the DRB1 gene provides a perfect tag for protective versus risk HLA-DRB1 four-digit alleles. In addition to the traditional role of the membrane-distal region of HLA class II molecules in antigen presentation and CD4 T-cell activation, the membrane-proximal region mediates 'non-traditional' multi-functional activation, differentiation, or death signals, including in DR-expressing T cells. To understand how HLA-DR contributes to disease pathogenesis, we examined expression at the protein level in circulating myeloid (CD14

Indexed as

Gene Expression RegulationGenetic Predisposition to DiseaseLymphocytesMyeloid CellsPolymorphism, Single NucleotideAdolescentAdultAllelesAntigens, CDChildChild, PreschoolFemaleHLA-DRB1 ChainsHomozygoteHumansInfantAntigens, CDHLA-DRB1 ChainsHLA-DRlymphoid lineageMHC Class II expressionmyeloid lineagevisceral leishmaniasis

Identifiers

PMID30403401
PMCPMC6328996
OpenAlexW2899741019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.