ArticleJournal of the American Chemical Society2018
n→π* Interactions Modulate the Properties of Cysteine Residues and Disulfide Bonds in Proteins.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities.Angewandte Chemie (International ed. in English) · 2026Article
- The Investigation of the Subtle Structural Discrepancies between Oryza Sativa Recombinant and Plasma-Derived Human Serum Albumins to Design a Novel Nanoparticle as a Taxane Delivery System.The protein journal · 2024Article
- Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling.Nature communications · 2023Article
- Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target.iScience · 2023Article
- A molecular descriptor of intramolecular noncovalent interaction for regulating optoelectronic properties of organic semiconductors.Nature communications · 2023Article
- Sulfur-mediated chalcogen versus hydrogen bonds in proteins: a see-saw effect in the conformational space.QRB discovery · 2023Article
- Intermolecular noncovalent interactions with carbon in solution.Chemical science · 2022Article
- Skeletal Ring Contractions via I(I)/I(III) Catalysis: Stereoselective Synthesis ofACS catalysis · 2022Article
- Context-Dependence of the Reactivity of Cysteine and Lysine Residues.Chembiochem : a European journal of chemical biology · 2022Article
- Leveraging the n→π* Interaction in Alkene Isomerization by Selective Energy Transfer Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Hydrogen Bonds and n → π* Interactions in the Acetylation of Propranolol Catalyzed byACS omega · 2021Article
- Article
- Increasing protein stability by engineering the n → π* interaction at the β-turn.Chemical science · 2020Article
- Disulfide Chromophores Arise from Stereoelectronic Effects.The journal of physical chemistry. B · 2020Article
- Structural preferences of cysteine sulfinic acid: The sulfinate engages in multiple local interactions with the peptide backbone.Free radical biology & medicine · 2020Article
- Origin of the Photoluminescence of Metal Nanoclusters: From Metal-Centered Emission to Ligand-Centered Emission.Nanomaterials (Basel, Switzerland) · 2020Review
- A Regulatory Cysteine Residue Mediates Reversible Inactivation of NADACS chemical biology · 2020Article
- The next generation of biopanning: next gen sequencing improves analysis of bacterial display libraries.BMC biotechnology · 2019Article
- Secondary Forces in Protein Folding.ACS chemical biology · 2019Review
- AnACS catalysis · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Noncovalent interactions are ubiquitous in biology, taking on roles that include stabilizing the conformation of and assembling biomolecules, and providing an optimal environment for enzymatic catalysis. Here, we describe a noncovalent interaction that engages the sulfur atoms of cysteine residues and disulfide bonds in proteins-their donation of electron density into an antibonding orbital of proximal amide carbonyl groups. This n→ π* interaction tunes the reactivity of the CXXC motif, which is the critical feature of thioredoxin and other enzymes involved in redox homeostasis. In particular, an n→ π* interaction lowers the p K
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