Evidence map›Paper›PMID 30402824›Full record

ArticleJournal of neurovirology2019

HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate.

Dorota Piekna-Przybylska, Kavyasri Nagumotu, Danielle M Reid, Sanjay B Maggirwar

Abstract read
In one paragraph

Article in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  5. Review
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  9. Review
  10. Article
  11. NADFrontiers in molecular biosciences · 2021
    Review
  12. Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  13. Article
  14. Review
  15. Drug discovery today. Disease models · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dorota Piekna-PrzybylskaDepartment of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. dorota_piekna@urmc.rochester.edu.ORCID 0000-0001-7328-9755
Kavyasri NagumotuDepartment of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
Danielle M ReidDepartment of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
Sanjay B MaggirwarDepartment of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
Platelet-mediated neuroinflammatory response to HIVR01NS066801 · NINDS · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B. · 2010 to 2020
$3.9M
Inflammatory mechanisms associated with HIV-1 dementiaR01NS054578 · NINDS · UNIVERSITY OF ROCHESTER · PI MAGGIRWAR, SANJAY B. · 2006 to 2016
$3.5M
DNA Damage Response in Latent HIV-1 ReservoirsR21AI131961 · NIAID · UNIVERSITY OF ROCHESTER · PI PIEKNA-PRZYBYLSKA, DOROTA LUCJA · 2018 to 2019
$424k
NIAID NIH HHS P30 AI078498NIAID NIH HHS R21 AI131961NINDS NIH HHS R01 NS054578NINDS NIH HHS R01 NS066801
6 · The paper itself

Abstract

Reduced pericytes' coverage of endothelium in the brain is one of the structural changes leading to breach of the blood-brain barrier during HIV infection. We previously showed in central memory T (T

Indexed as

AstrocytesAtaxia Telangiectasia Mutated ProteinsBenzamidesBrainChromonesDNADNA-Activated Protein KinaseDNA DamageGene Expression RegulationGlutamic AcidHistonesHIV-1Host-Pathogen InteractionsHumansInterleukin-1betaMorpholines2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one3-aminobenzamide8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-oneAtaxia Telangiectasia Mutated ProteinsATM protein, humanBenzamidesChromonesDNADNA-Activated Protein KinaseGlutamic AcidH2AX protein, humanHistonesIL1B protein, humanInterleukin-1betaMorpholinesPoly(ADP-ribose) PolymerasesPRKDC protein, humanPyronesTumor Necrosis Factor-alphaAstrocytesCentral memory T cellsDNA damage responseGlutamateHIV latencyPericytes

Identifiers

PMID30402824
PMCPMC6417930
OpenAlexW2900240315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.