Evidence map›Paper›PMID 30402822›Full record

ArticleJournal of general internal medicine2019

Influence of Age, Health, and Function on Cancer Screening in Older Adults with Limited Life Expectancy.

Nancy L Schoenborn, Jin Huang, Orla C Sheehan, Jennifer L Wolff, David L Roth, Cynthia M Boyd

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Social Drivers of Guideline-Discordant Breast Cancer Screening by Age and Mortality Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Risk of Colorectal Cancer and Colorectal Cancer Mortality Beginning Ten Years after a Negative Colonoscopy, among Screen-Eligible Adults 76 to 85 Years Old.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nancy L SchoenbornThe Johns Hopkins School of Medicine, Baltimore, MD, USA. nancyli@jhmi.edu.
Jin HuangThe Johns Hopkins School of Medicine, Baltimore, MD, USA.
Orla C SheehanThe Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jennifer L WolffThe Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.
David L RothThe Johns Hopkins School of Medicine, Baltimore, MD, USA.
Cynthia M BoydThe Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Prognostic Significance of Family Caregiver Factors for Older Adult Health EventsR01AG047859 · NIA · JOHNS HOPKINS UNIVERSITY · PI WOLFF, JENNIFER L. · 2015 to 2018
$1.5M
Patient-Centered Care for Older Adults with Multiple Chronic Conditions: Research and Mentoring ProgramK24AG056578 · NIA · JOHNS HOPKINS UNIVERSITY · PI BOYD, CYNTHIA MELINDA · 2017 to 2021
$1.1M
Improving cancer screening in older adults with limited life expectancyK76AG059984 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHOENBORN, NANCY · 2018 to 2021
$972k
Understanding Older Adults' Perspectives on How to Incorporate Life Expectancy in Cancer ScreeningR03AG050912 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHOENBORN, NANCY · 2015 to 2016
$243k
NCATS NIH HHS KL2 TR001077NIA NIH HHS K24 AG056578NIA NIH HHS K76 AG059984NIA NIH HHS R01 AG047859NIA NIH HHS R03 AG050912
6 · The paper itself

Abstract

BACKGROUND/

objectivesWe examined the relationship between cancer screening and life expectancy predictors, focusing on the influence of age versus health and function, in older adults with limited life expectancy.

designLongitudinal cohort study

settingNational Health and Aging Trends Study (NHATS) with linked Medicare claims.

participantsThree cohorts of adults 65+ enrolled in fee-for-service Medicare were constructed: women eligible for breast cancer screening (n = 2043); men eligible for prostate cancer screening (n = 1287); men and women eligible for colorectal cancer screening (n = 3759). MEASUREMENTS: We assessed 10-year mortality risk using 2011 NHATS data, then used claims data to assess 2-year prostate and breast cancer screening rates and 3-year colorectal cancer screening rates. Among those with limited life expectancy (10-year mortality risk > 50%), we stratified participants at each level of predicted mortality risk and split participants in each risk stratum by the median age. We assembled two sub-groups from these strata that were matched on predicted life expectancy: a "younger sub-group" with relatively poorer health/functional status and an "older sub-group" with relatively better health/functional status. We compared screening rates between sub-groups.

resultsFor all three cancer screenings, the younger sub-groups (average ages 73.4-76.1) had higher screening rates than the older sub-groups (average ages 83.6-86.9); screening rates were 42.9% versus 34.2% for prostate cancer screening (p = 0.02), 33.6% versus 20.6% for breast cancer screening (p < 0.001), 13.1% versus 6.7% for colorectal cancer screening in women (p = 0.006), and 20.5% versus 12.1% for colorectal cancer screening in men (p = 0.002).

conclusionAmong older adults with limited life expectancy, those who are relatively younger with poorer health and functional status are over-screened for cancer at higher rates than those who are older with the same predicted life expectancy.

Indexed as

Activities of Daily LivingHealth StatusAgedAged, 80 and overAge DistributionAge FactorsBreast NeoplasmsColorectal NeoplasmsEarly Detection of CancerFemaleFollow-Up StudiesHumansLife ExpectancyMaleMorbidityProstatic Neoplasmscancer screeningfunctional statusgeriatricshealth status

Identifiers

PMID30402822
PMCPMC6318172
OpenAlexW2900159347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.