Evidence map›Paper›PMID 30402793›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Tranexamic acid and post-tonsillectomy hemorrhage: propensity score and instrumental variable analyses.

Megumi Koizumi, Miho Ishimaru, Hiroki Matsui, Kiyohide Fushimi, Tatsuya Yamasoba, Hideo Yasunaga

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Observational
  3. Article
  4. Review
  5. Article
  6. Article
  7. Tranexamic acid in otorhinolaryngology - A contemporary review.World journal of otorhinolaryngology - head and neck surgery · 2021
    Review
  8. Article
  9. Article
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Megumi KoizumiDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 1130033, Japan. imegumi-zao@umin.ac.jp.ORCID http://orcid.org/0000-0002-3133-5845
Miho IshimaruDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 1130033, Japan.
Hiroki MatsuiDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 1130033, Japan.
Kiyohide FushimiDepartment of Health Policy and Informatics, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tatsuya YamasobaDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hideo YasunagaDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 1130033, Japan.
The University of Tokyo · JPTokyo Medical and Dental University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 17H04141Ministry of Health, Labour and Welfare (JP) H29-ICT-General-004Ministry of Health, Labour and Welfare (JP) H30-Policy-Designated-004
6 · The paper itself

Abstract

purposeAlthough post-tonsillectomy hemorrhage occurs rarely, it can be life-threatening. Previous studies showed that tranexamic acid (TXA) had insignificant association with the rate of post-tonsillectomy hemorrhage, but those findings were limited by small sample sizes. The purpose of this study was to examine the effectiveness of TXA in preventing post-tonsillectomy hemorrhage using nationwide database.

methodsData of a retrospective cohort of 117,598 patients from 750 hospitals, who had undergone tonsillectomy between 2010 and 2016, were drawn from the Diagnosis Procedure Combination database in Japan and studied.

resultsPropensity score-matched analysis showed no significant differences in proportions of reoperation or blood transfusion after tonsillectomy between the treatment (TXA from the day of tonsillectomy) and control groups (1.50% vs. 1.47%, p = 0.64). Instrumental variable analysis also showed no significant differences (odds ratio, 0.98; 95% confidence interval, 0.86-1.13; p = 0.82). Higher proportions of reoperation or blood transfusion were significantly associated with male sex, older age, emergency hospitalization, prolonged anesthesia, and medium hospital volume (annual number of tonsillectomies).

conclusionsAdministration of TXA from the day of tonsillectomy is not associated with reduction in reoperation or blood transfusion rates.

Indexed as

Propensity ScoreAdolescentAdultAntifibrinolytic AgentsDatabases, FactualFemaleHumansIncidenceJapanMaleMiddle AgedOdds RatioPostoperative HemorrhageRetrospective StudiesTonsillectomyTranexamic AcidAntifibrinolytic AgentsTranexamic AcidInstrumental variable analysisPost-tonsillectomy hemorrhagePropensity score matchingReoperation for hemostasisTranexamic acid

Identifiers

PMID30402793
OpenAlexW2900151972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.