Evidence map›Paper›PMID 30402785›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Enhanced Desorption Electrospray Ionization Mass Spectrometry via Synchronizing Ion Generation and Ion Injection.

Zhuanghao Hou, Xingchuang Xiong, Xiang Fang, Guangming Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhuanghao HouDepartment of Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China (USTC), Hefei, Anhui, 230026, People's Republic of China.
Xingchuang XiongNational Institute of Metrology, Beijing, 100013, People's Republic of China.
Xiang FangNational Institute of Metrology, Beijing, 100013, People's Republic of China. fangxiang@nim.ac.cn.
Guangming HuangDepartment of Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China (USTC), Hefei, Anhui, 230026, People's Republic of China. gmhuang@ustc.edu.cn.ORCID http://orcid.org/0000-0002-8391-4013

Funding

National Key Research and Development Program of China 2016YFA0201300the Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology 2017FXCX003the National Natural Science Foundation of China 21475121the National Natural Science Foundation of China 21775143
6 · The paper itself

Abstract

A modified version of desorption electrospray ionization mass spectrometry was developed for (i) better utilization of analyte ions and (ii) larger sampling area via synchronization the pulsed nebulizer gas with ion injection. To synchronize the sheath gas, gas flow was paused for 50 ms within each cycle, leading to solvent accumulation at the end of emitter tip. That solvent accumulation enlarged the desorption areas. As a result, the amount of analytes increased. Thus, the improved signal intensity (~ 2-5-folds for various substrates) was benefit from both better analyte ion utilization and larger desorption areas. Finally, the enhanced signal intensity was confirmed with both garlic homogenate and brain homogenate. Graphical Abstract ᅟ.

Indexed as

Ion generationIon injectionMass spectrometerSignal enhancementSynchronized desorption electrospray ionization

Identifiers

PMID30402785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.