ArticleEJNMMI research2018
Performance evaluation of the next generation solid-state digital photon counting PET/CT system.
Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed.
- Assessing small-lesion detectability and acquisition time optimisation in silicon-detector-Based PET: a phantom study.EJNMMI physics · 2025Article
- Utility of plasma circulating DNA tumor fraction in bone-only metastatic breast cancer: a real-world outcomes study.Breast cancer research and treatment · 2025Article
- UR-cycleGAN: Denoising full-body low-dose PET images using cycle-consistent Generative Adversarial Networks.Journal of applied clinical medical physics · 2025Article
- Improvement of image quality for small lesion sizes inAsia Oceania journal of nuclear medicine & biology · 2025Article
- High PhysiologicalWorld journal of nuclear medicine · 2024Article
- Reduction of [EJNMMI physics · 2024Article
- Comparative study of physiological FDG uptake in small structures between silicon photomultiplier-based PET and conventional PET.Annals of nuclear medicine · 2024Article
- Potential Clinical Impact of LAFOV PET/CT: A Systematic Evaluation of Image Quality and Lesion Detection.Diagnostics (Basel, Switzerland) · 2023Article
- Impact of list-mode reconstruction and image-space point spread function correction on PET image contrast and quantitative value using SiPM-based PET/CT system.Radiological physics and technology · 2023Article
- The Potential Role of PET in the Management of Peripheral Artery Disease.Current cardiology reports · 2023Review
- Deep Learning Denoising Improves and Homogenizes Patient [Diagnostics (Basel, Switzerland) · 2023Article
- Advances in Digital PET Technology and Its Potential Impact on Myocardial Perfusion and Blood Flow Quantification.Current cardiology reports · 2023Review
- Comparison of Image Quality and Quantification Parameters between Q.Clear and OSEM Reconstruction Methods on FDG-PET/CT Images in Patients with Metastatic Breast Cancer.Journal of imaging · 2023Article
- Article
- Technical opportunities and challenges in developing total-body PET scanners for mice and rats.EJNMMI physics · 2023Review
- Detection of lymph node metastases in patients with prostate cancer: Comparing conventional and digital [Clinical physiology and functional imaging · 2022Article
- Small nuclei identification with a hemispherical brain PET.EJNMMI physics · 2022Article
- Artificial intelligence-based PET denoising could allow a two-fold reduction in [European journal of nuclear medicine and molecular imaging · 2022Article
- A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET.European journal of nuclear medicine and molecular imaging · 2022Article
- Advances in Preclinical PET.Seminars in nuclear medicine · 2022Review
3 more citing papers are in PubMed but not listed here.
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Abstract
backgroundThe first solid-state silicon photomultiplier (SiPM) digital photon counting (DPC) clinical PET/CT system was introduced by Philips in recent years. The system differs from other SiPM-based PET/CT systems and uses lutetiumyttrium oxyorthosilicate (LYSO) scintillators directly coupled with their own individual SiPM DPC detectors eliminating the need for Anger-logic positioning decoding. We evaluated the system performance, characteristics, and stability of the next generation DPC clinical PET/CT based on NEMA NU2-2012 tests, NEMA NU2-2018 test (timing resolution) and human studies.
resultsAn energy resolution of 11.2% was measured. NEMA NU2-2012 tests revealed a spatial resolution (mm in FWHM) from (3.96, 4.01, 4.01) at 1 cm to (5.81, 5.83, 4.95) at 20 cm for (axial, radial, tangential). A 5.7 cps/kBq system sensitivity was measured. Peak noise equivalent count rate (NECR) and peak true count rate could not be determined as each exhibited increasing values up to the maximum activity measured (~ 1100 MBq). The maximum NECR was 171 kcps @ 50.5 kBq/mL, with corresponding scatter fraction of 30.8% and maximum trues of 681 kcps. NEMA hot sphere contrast ranged from 62% (10 mm) to 88% (22 mm), cold sphere contrast of 86% (28 mm) and 89% (37 mm). A timing resolution of 322 ps (
conclusionsThis scanner represents the first solid-state DPC PET/CT, a technologic leap beyond photomultipliers tubes and anger logic. It presents considerable improvements in system performance and characteristics with excellent time-of-flight capability compared to conventional photomultiplier tube (PMT) PET/CT systems. The DPC system leads to promising clinical opportunities with excellent image quality, lesion detectability, and diagnostic confidence.
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