ArticleEuropean radiology experimental2018
Emphysema quantification using chest CT: influence of radiation dose reduction and reconstruction technique.
Article in European radiology experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantification of progressive pulmonary fibrosis by visual scoring of HRCT images: recommendations from Italian chest radiology experts.La Radiologia medica · 2025Guideline
- The Impact of CT Reconstruction Parameters on Emphysema Index Quantification, HU-Based Measurements, and Goddard Score in COPD Assessment: A Prospective Study.International journal of biomedical imaging · 2026Article
- Reproducibility of lung density quantification across photon-counting and conventional energy-integrating CT: a comparative study.The British journal of radiology · 2025Article
- Harmonized low-dose computed tomographic protocols for quantitative lung imaging using dose modulation and advanced reconstructions.Medical physics · 2025Article
- Coronary calcium score and emphysema extent on different CT radiation dose protocols in lung cancer screening.European radiology · 2025Article
- A systematic assessment and optimization of photon-counting CT for lung density quantifications.Medical physics · 2024Article
- Screening and staging of chronic obstructive pulmonary disease with deep learning based on chest X-ray images and clinical parameters.BMC pulmonary medicine · 2024Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Single-material beam hardening correction via an analytical energy response model for diagnostic CT.Medical physics · 2022Article
- Performance of virtual non-contrast images generated on clinical photon-counting detector CT for emphysema quantification: proof of concept.The British journal of radiology · 2022Article
- Application of deep learning image reconstruction in low-dose chest CT scan.The British journal of radiology · 2022Article
- Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests.International journal of nanomedicine · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- Improved precision of noise estimation in CT with a volume-based approach.European radiology experimental · 2021Article
- Ultra-Small Lung Cysts Impair Diffusion Without Obstructing Air Flow in Lymphangioleiomyomatosis.Chest · 2021Article
- Computed tomography semi-automated lung volume quantification in SARS-CoV-2-related pneumonia.European radiology · 2021Article
- Clinical CT underestimation of the percentage volume occupied by cysts in patients with lymphangioleiomyomatosis.Clinical imaging · 2020Article
- Optimization of pulmonary emphysema quantification on CT scans of COPD patients using hybrid iterative and post processing techniques: correlation with pulmonary function tests.Insights into imaging · 2019Article
- In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica.European radiology experimental · 2019Article
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10 authors.
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Abstract
backgroundComputed tomography (CT) emphysema quantification is affected by both radiation dose (i.e. image noise) and reconstruction technique. At reduced dose, filtered back projection (FBP) results in an overestimation of the amount of emphysema due to higher noise levels, while the use of iterative reconstruction (IR) can result in an underestimation due to reduced noise. The objective of this study was to determine the influence of dose reduction and hybrid IR (HIR) or model-based IR (MIR) on CT emphysema quantification.
methodsTwenty-two patients underwent inspiratory chest CT scan at routine radiation dose and at 45%, 60% and 75% reduced radiation dose. Acquisitions were reconstructed with FBP, HIR and MIR. Emphysema was quantified using the 15th percentile of the attenuation curve and the percentage of voxels below -950 HU. To determine whether the use of a different percentile or HU threshold is more accurate at reduced dose levels and with IR, additional measurements were performed using different percentiles and HU thresholds to determine the optimal combination.
resultsDose reduction resulted in a significant overestimation of emphysema, while HIR and MIR resulted in an underestimation. Lower HU thresholds with FBP at reduced dose and higher HU thresholds with HIR and MIR resulted in emphysema percentages comparable to the reference. The 15th percentile quantification method showed similar results as the HU threshold method.
conclusionsThis within-patients study showed that CT emphysema quantification is significantly affected by dose reduction and IR. This can potentially be solved by adapting commonly used thresholds.
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