ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2018
New mechanisms of phenytoin in calcium homeostasis: competitive inhibition of CD38 in hippocampal cells.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- CALB2 Overexpression Attenuates Neuropathic Pain by Inhibiting Oxidative Stress and Modulating Microglia M1/M2 Polarization Through Activation of the cAMP/CREB Pathway.Neurochemical research · 2025Article
- Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells.Clinical & translational immunology · 2024Article
- Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing CaRSC advances · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePhenytoin is a major anticonvulsant drug that is effective to improve arrhythmia and neuropathic pain. According to early works, phenytoin affected cell membrane depolarization by sodium channel blocking, guanylyl and adenylyl cyclase suppression that cause to intracellular Na
methodsIn this study intracellular free Ca
resultsOur results confirmed phenytoin competitively inhibits cyclase activity of CD38 (IC
conclusionTaken together, one of the anticonvulsant mechanisms of phenytoin is Ca
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Registered trials
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