ReviewCurrent psychiatry reports2018
A Review of the Neurobiological Basis of Trauma-Related Dissociation and Its Relation to Cannabinoid- and Opioid-Mediated Stress Response: a Transdiagnostic, Translational Approach.
Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Treatment of dissociative symptoms with opioid antagonists: a systematic review.European journal of psychotraumatology · 2023Pooled it
- Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients.European journal of psychotraumatology · 2022Pooled it
- Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.Psychopharmacology · 2024Trial
- A randomized controlled trial of Deep Brain Reorienting: a neuroscientifically guided treatment for post-traumatic stress disorder.European journal of psychotraumatology · 2023Trial
- Prevalence, psychiatric comorbidity and treatment of multiple personality disorder in Germany: an analysis based on nationwide claims data, 2012-2021.European journal of psychotraumatology · 2026Observational
- The Revised ACE Pyramid: A Contemporary Framework for Understanding Childhood Adversity and Advancing Toxic Stress Prevention and Healing.Children (Basel, Switzerland) · 2026Article
- Emotion regulation strategy use and daily levels of affective arousal, affective valence and dissociation in a clinical sample.Scientific reports · 2026Article
- Dissociative symptoms during the SARS-CoV-2 pandemic situation in mental health patients.Borderline personality disorder and emotion dysregulation · 2026Article
- Clay field therapy for complex PTSD: a single-case study with HRV measurement.Frontiers in psychiatry · 2026Article
- The interoceptive communication model (ICM 2.0): a state-dependent neurophysiological framework for behavioral and cognitive accessibility.Frontiers in psychology · 2026Article
- A network analysis of peritraumatic dissociation and subsequent intrusive memories.European journal of psychotraumatology · 2025Article
- Amygdala-targeted neurofeedback for dissociative symptoms in PTSD: Converging evidence from three independent studies.Psychiatry research · 2025Article
- Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype.Neuroimage. Reports · 2025Article
- Proposition of Two Subtypes of Patients at Risk of Suicide: Pain Hypersensitive Vs. Dissociative.Current psychiatry reports · 2025Review
- Dissociative experiences alter resting state functional connectivity after childhood abuse.Scientific reports · 2025Article
- Temporal depth in a coherent self and in depersonalization: theoretical model.Frontiers in psychology · 2025Article
- Dissociative Symptoms and Interoceptive Integration.Current topics in behavioral neurosciences · 2025Review
- Neuroscience-based relational art therapy and deep brain reorienting in the treatment of dissociative identity disorder.Frontiers in psychology · 2025Article
- Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Treatment of dissociative identity disorder: leveraging neurobiology to optimize success.Expert review of neurotherapeutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dissociative experiences have been associated with increased disease severity, chronicity, and, in some cases, reduced treatment response across trauma-related and other psychiatric disorders. A better understanding of the neurobiological mechanisms through which dissociative experiences occur may assist in identifying novel pharmacological and non-pharmacological treatment approaches. Here, we review emerging work on the dissociative subtype of posttraumatic stress disorder (PTSD), and other trauma-related disorders providing evidence for two related overarching neurobiological models of dissociation, the defense cascade model of dissociation and Mobb's threat detection model. In particular, we review neuroimaging studies highlighting alterations in functional connectivity of key brain regions associated with these models, including connectivity between the prefrontal cortex, the amygdala and its complexes, the insula, and the periaqueductal gray. Work implicating the kappa-opioid and endocannabinoid systems in trauma-related dissociative experiences is also reviewed. Finally, we hypothesize mechanisms by which pharmacological modulation of these neurochemical systems may serve as promising transdiagnostic treatment modalities for individuals experiencing clinically significant levels of dissociation. Specifically, whereas kappa-opioid receptor antagonists may serve as a pharmacological vehicle for the selective targeting of dissociative symptoms and associated emotion overmodulation in the dissociative subtype of posttraumatic stress disorder and transdiagnostically, modulation of the endocannabinoid system may reduce symptoms associated with emotional undermodulation of the fight or flight components of the defense cascade model.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.