Evidence map›Paper›PMID 30402674›Full record

ArticleEndocrine2019

Assessing the predictive accuracy of oral glucose effectiveness index using a calibration model.

Michael Glicksman, Shivraj Grewal, Shrayus Sortur, Brent S Abel, Sungyoung Auh, Trudy R Gaillard, Kwame Osei, Ranganath Muniyappa

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael GlicksmanDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA.
Shivraj GrewalDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA.
Shrayus SorturDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA.
Brent S AbelDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA.
Sungyoung AuhDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA.
Trudy R GaillardNicole Wertheim College of Nursing and Health Sciences, Florida International University, Miami, FL, USA.
Kwame OseiDivision of Endocrinology, Diabetes and Metabolism, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Ranganath MuniyappaDiabetes, Endocrinology, and Obesity Branch, NIDDK, Bethesda, MD, USA. muniyapr@mail.nih.gov.

Funding

University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
Biobehavioral Studies of Obesity, Weight loss and RecidivismZIADK075007 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MUNIYAPPA, RANGANATH · 2009 to 2025
$13.8M
Intramural NIH HHS ZIA DK075007NCRR NIH HHS UL1 RR025755NIDDK NIH HHS Intramural Research Program
6 · The paper itself

Abstract

purposeCurrent reference methods for measuring glucose effectiveness (GE) are the somatostatin pancreatic glucose clamp and minimal model analysis of frequently sampled intravenous glucose tolerance test (FSIVGTT), both of which are laborious and not feasible in large epidemiological studies. Consequently, surrogate indices derived from an oral glucose tolerance test (OGTT) to measure GE (oGE) have been proposed and used in many studies. However, the predictive accuracy of these surrogates has not been formally validated. In this study, we used a calibration model analysis to evaluate the accuracy of surrogate indices to predict GE from the reference FSIVGTT (Sg

methodsSubjects (n = 123, mean age 48 ± 11 years; BMI 35.9 ± 7.3 kg/m

resultsAs expected, insulin sensitivity, Sg

conclusionsAlthough OGTT-derived surrogate indices of GE are convenient and feasible, they have limited ability to robustly predict GE.

Indexed as

Health Status IndicatorsModels, BiologicalAdministration, IntravenousAdministration, OralAdultBlood GlucoseCalibrationCohort StudiesDiabetes Mellitus, Type 2FemaleGlucoseGlucose Clamp TechniqueGlucose IntoleranceGlucose Tolerance TestHumansInsulin ResistanceBlood GlucoseGlucoseAccuracyDiabetesGlucose effectivenessSurrogate index

Identifiers

PMID30402674
PMCPMC6448593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.