ArticleBioMed research international2018
An Evaluation of Clinical and Histopathological Aspects of Patients with Oral Submucous Fibrosis in the Background of Oral Squamous Cell Carcinoma.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Diagnosing malignant transformation potential in oral submucous fibrosis with leukoplakia: an approach utilizing deoxyribonucleic acid image cytometry.Scientific reports · 2025Article
- Research progress on the role of decorin in the development of oral mucosal carcinogenesis.Oncology research · 2025Review
- MicroRNA-503 Suppresses Oral Mucosal Fibroblast Differentiation by Regulating RAS/RAF/MEK/ERK Signaling Pathway.Biomolecules · 2024Article
- A study of risk factors associated with the presence of oral potentially malignant disorders: a community-based study from Northeastern Thailand.BMC oral health · 2024Article
- Role of programmed cell death 4 in myofibroblast differentiation in oral submucous fibrosis.Journal of oral and maxillofacial pathology : JOMFPArticle
- A retrospective study of clinicopathological features of oral squamous cell carcinoma with and without oral submucous fibrosis.Journal of oral and maxillofacial pathology : JOMFPArticle
- Unexpected additional pathologies at the surgical margins of oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- Meta-analysis on risk factors of squamous cell carcinoma of the tongue in young adults.Journal of oral and maxillofacial pathology : JOMFPReview
- The Stromal Dictators in a Concomitant Case of Oral Submucous Fibrosis - Oral Squamous Cell Carcinoma.International journal of applied & basic medical researchArticle
- PTEN and α-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis.Journal of oral & maxillofacial researchArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe behavior and prognosis of oral squamous cell carcinoma (OSCC) is presumably different in patients with oral submucous fibrosis (OSF). The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of OSF to OSCC.
methodsData were extracted from the archives and histopathological evaluation and presence of nodal metastasis were recorded.
resultsOSF was detected in 130 (48%) out of 273 OSCC patients. The mean age of presentation among OSF-positive patients was 57.7 years, while patients diagnosed only with OSCC had a comparatively higher age, 59.5 years. In the below 50 years of age group, presence of OSF with OSCC was less (40%). In the OSF-positive group, male to female ratio was 3.2:1. The common primary sites were buccal mucosa and tongue in both groups. Betel quid chewing was present in more than 95% of the sample. Betel chewing, smoking, and alcohol consumption were present in 26.15% of OSF-positive patients. Degree of fibrosis was neither associated with the level of histological differentiation of the tumor (p= 0.195) nor associated with the malignant transformation (p =0.373). Lymph node metastasis was not seen in 76.63% and 68.54% of the patients with and without OSF, respectively.
conclusionsHigh degree of prevalence of OSF was observed among the OSCC patients. There were also a male predilection and younger age at presentation in these patients. However, a significant association was not observed in the degree of fibrosis with malignant transformation or the level of histopathological differentiation of the tumor. Lymph node metastasis also failed to express a significant relationship with the presence of OSF.
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