ArticleNeurology research international2018
The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.
Article in Neurology research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04149379 (Hyperbaric Oxygen Therapy After Cerebral Infarction - PILOT), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hyperbaric Oxygen Therapy After Cerebral Infarction - PILOT
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.Frontiers in neurology · 2025Pooled it
- Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review.Neuropsychology review · 2022Pooled it
- The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis.Biomolecules · 2021Pooled it
- Efficacy and safety of hyperbaric oxygen therapy for women with fibromyalgia: a systematic review and meta-analysis of randomized controlled trials.Reumatologia · 2026Article
- Hyperbaric Oxygen Therapy in Children with Brain Injury: A Retrospective Case Series.International journal of medical sciences · 2025Article
- Hyperbaric oxygen therapy for poststroke insomnia: a systematic review and meta-analysis protocol.BMJ open · 2024Article
- Hyperbaric oxygen therapy for thalamic pain syndrome: case report.Frontiers in neurology · 2024Article
- Functional MRI evaluation of hyperbaric oxygen therapy effect on hand motor recovery in a chronic post-stroke patient: a case report and physiological discussion.Frontiers in neurology · 2023Article
- Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.Biomolecules · 2021Review
- Article
- Hyperbaric Oxygen Improves Cerebral Ischemia/Reperfusion Injury in Rats Probably via Inhibition of Autophagy Triggered by the Downregulation of Hypoxia-Inducing Factor-1 Alpha.BioMed research international · 2021Article
- Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series.International journal of environmental research and public health · 2020Article
- Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions.Biomolecules · 2020Review
- Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis.Restorative neurology and neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits.
objectiveTo investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke.
methodsUsing a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7). Each subject then received two 4-week periods of HBOT for a total of 40 90-minute treatments over a 12-week period. Subjects completed a battery of assessments and had blood drawn six times over the 9-month total duration of the study.
resultsWe found improvements in cognition and executive function as well as physical abilities, specifically, improved gait. Participants reported improved sleep and quality of life following HBOT treatment. We also saw changes in serum levels of biomarkers for inflammation and neural recovery. In the functional domains where improvement was observed following HBOT treatment, the improvements were maintained up to 3 months following the last treatment. However, the physiological biomarkers showed a pattern of more transient changes following HBOT treatment.
conclusionsFindings from this study support the idea of HBOT as a potential intervention following stroke.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.