Evidence map›Paper›PMID 30402262›Full record

ArticleNeuro-oncology practice2018

Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging.

Mariam S Aboian, Cassie N Kline, Yi Li, David A Solomon, Erin Felton, Anu Banerjee, Steve E Braunstein, Sabine Mueller, William P Dillon, Soonmee Cha

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Unleashing the Mystery of a Treated Case of Medulloblastoma.The Indian journal of radiology & imaging · 2022
    Article
  6. Article
  7. MR Imaging of Pediatric Brain Tumors.Diagnostics (Basel, Switzerland) · 2022
    Review
  8. Updates on Management of Adult Medulloblastoma.Current treatment options in oncology · 2019
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mariam S AboianDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
Cassie N KlineDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco, San Francisco CA.
Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
David A SolomonDepartment of Pathology, University of California San Francisco, San Francisco CA.
Erin FeltonDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco, San Francisco CA.
Anu BanerjeeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
Steve E BraunsteinDepartment of Radiation Oncology, University of California San Francisco, San Francisco CA.
Sabine MuellerDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco, San Francisco CA.
William P DillonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
Soonmee ChaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
University of California, San Francisco · USUniversity of California System · USNeurological Surgery · US

Funding

Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
NCI NIH HHS T32 CA128583
6 · The paper itself

Abstract

backgroundImaging diagnosis of medulloblastoma recurrence relies heavily on identifying new contrast-enhancing lesions on surveillance imaging, with diffusion-weighted imaging (DWI) being used primarily for detection of complications. We propose that DWI is more sensitive in detecting distal and leptomeningeal recurrent medulloblastoma than T1-weighted postgadolinium imaging.

methodsWe identified 53 pediatric patients with medulloblastoma, 21 of whom developed definitive disease recurrence within the brain. MRI at diagnosis of recurrence and 6 months prior was evaluated for new lesions with reduced diffusion on DWI, contrast enhancement, size, and recurrence location.

resultsAll recurrent medulloblastoma lesions demonstrated reduced diffusion. Apparent diffusion coefficient (ADC) measurements were statistically significantly lower (

conclusionRecurrent medulloblastoma lesions do not uniformly demonstrate contrast enhancement on MRI, but all demonstrate reduced diffusion. Our findings support that DWI is more sensitive than contrast enhancement for detection of medulloblastoma recurrence, particularly in cases of leptomeningeal nonenhancing disease and distal nonenhancing focal disease. As such, recurrent medulloblastoma can present as a reduced diffusion lesion in a patient with normal postgadolinium contrast MRI.

Indexed as

diffusionDWIleptomeningealmedulloblastomametastasis

Identifiers

PMID30402262
PMCPMC6213943
OpenAlexW2793064511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.