Evidence map›Paper›PMID 30402042›Full record

ArticleMediators of inflammation2018

Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation.

Nattawan Suwannakul, Ning Ma, Raynoo Thanan, Somchai Pinlaor, Piti Ungarreevittaya, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Notch Signaling Pathway in Pancreatobiliary Tumors.Medicina (Kaunas, Lithuania) · 2021
    Article
  9. Review
  10. High Levels of Serum IgG forInternational journal of general medicine · 2021
    Article
  11. CD44 as a tumor biomarker and therapeutic target.Experimental hematology & oncology · 2020
    Review
  12. Targeting cancer stem cells in cholangiocarcinoma (Review).International journal of oncology · 2020
    Review
  13. CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma.Frontiers in cell and developmental biology · 2020
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nattawan SuwannakulDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Ning MaGraduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan.ORCID 0000-0001-7315-8835
Raynoo ThananDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Somchai PinlaorCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Piti UngarreevittayaCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Kaoru MidorikawaDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Yusuke HirakuDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Shinji OikawaDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Shosuke KawanishiFaculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan.ORCID 0000-0002-7525-7658
Mariko MurataDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.ORCID 0000-0003-3668-7214
Mie University · JPKhon Kaen University · THSuzuka University of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various CD44 isoforms are expressed in several cancer stem cells during tumor progression and metastasis. In particular, CD44 variant 9 (CD44v9) is highly expressed in chronic inflammation-induced cancer. We investigated the expression of CD44v9 and assessed whether CD44v9 is a selective biomarker of human cholangiocarcinoma (CCA). The expression profile of CD44v9 was evaluated in human liver fluke

Indexed as

AdultCalcium-Binding ProteinsCholangiocarcinomaCyclooxygenase 2FemaleHumansHyaluronan ReceptorsInflammationLiverMaleNeoplasm ProteinsNeoplastic Stem CellsCalcium-Binding ProteinsCD44 protein, humanCyclooxygenase 2Hyaluronan ReceptorsNeoplasm ProteinsS100P protein, human

Identifiers

PMID30402042
PMCPMC6198546
OpenAlexW2897382595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.