ArticleScientific reports2018
Ectopic beats arise from micro-reentries near infarct regions in simulations of a patient-specific heart model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 49 citations in OpenAlex.
- Toward cardiac electrophysiology digital twins with an efficient open source scalable solver on GPU clusters.Scientific reports · 2026Article
- Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation.Frontiers in network physiology · 2026Article
- The Impact of Basal Inflammatory Status on Post-CABG Atrial and Ventricular Ectopy and Remodeling Pathways.Medicina (Kaunas, Lithuania) · 2025Article
- Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue.Scientific reports · 2024Article
- 'Trapped re-entry' as source of acute focal atrial arrhythmias.Cardiovascular research · 2024Article
- Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy.Frontiers in physiology · 2024Article
- A smoothed boundary bidomain model for cardiac simulations in anatomically detailed geometries.PloS one · 2023Article
- Homogenisation for the monodomain model in the presence of microscopic fibrotic structures.Communications in nonlinear science & numerical simulation · 2023Article
- Graph-based homogenisation for modelling cardiac fibrosis.Journal of computational physics · 2022Article
- Effects of Acute Potassium Chloride Administration on Ventricular Dysrhythmias after Myocardial Infarction in a Rat Model of Ischemia/Reperfusion.The journal of Tehran Heart Center · 2022Article
- Ventricular Arrhythmias in Ischemic Cardiomyopathy-New Avenues for Mechanism-Guided Treatment.Cells · 2021Review
- Percolation and tortuosity in heart-like cells.Scientific reports · 2021Article
- CombinedFrontiers in physiology · 2021Article
- Machine Learning Identification of Pro-arrhythmic Structures in Cardiac Fibrosis.Frontiers in physiology · 2021Article
- 3D Electrophysiological Modeling of Interstitial Fibrosis Networks and Their Role in Ventricular Arrhythmias in Non-Ischemic Cardiomyopathy.IEEE transactions on bio-medical engineering · 2020Article
- Creation and application of virtual patient cohorts of heart models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Uncertainty quantification and sensitivity analysis of left ventricular function during the full cardiac cycle.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- An audit of uncertainty in multi-scale cardiac electrophysiology models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Review
- Variability in electrophysiological properties and conducting obstacles controls re-entry risk in heterogeneous ischaemic tissue.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Factors Promoting Conduction Slowing as Substrates for Block and Reentry in Infarcted Hearts.Biophysical journal · 2019Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectopic beats are known to be involved in the initiation of a variety of cardiac arrhythmias. Although their location may vary, ectopic excitations have been found to originate from infarct areas, regions of micro-fibrosis and other heterogeneous tissues. However, the underlying mechanisms that link ectopic foci to heterogeneous tissues have yet to be fully understood. In this work, we investigate the mechanism of micro-reentry that leads to the generation of ectopic beats near infarct areas using a patient-specific heart model. The patient-specific geometrical model of the heart, including scar and peri-infarct zones, is obtained through magnetic resonance imaging (MRI). The infarct region is composed of ischemic myocytes and non-conducting cells (fibrosis, for instance). Electrophysiology is captured using an established cardiac myocyte model of the human ventricle modified to describe ischemia. The simulation results clearly reveal that ectopic beats emerge from micro-reentries that are sustained by the heterogeneous structure of the infarct regions. Because microscopic information about the heterogeneous structure of the infarct regions is not available, Monte-Carlo simulations are used to identify the probabilities of an infarct region to behave as an ectopic focus for different levels of ischemia and different percentages of non-conducting cells. From the proposed model, it is observed that ectopic beats are generated when a percentage of non-conducting cells is near a topological metric known as the percolation threshold. Although the mechanism for micro-reentries was proposed half a century ago to be a source of ectopic beats or premature ventricular contractions during myocardial infarction, the present study is the first to reproduce this mechanism in-silico using patient-specific data.
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