ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Predictors of confirmatory test results for the diagnosis of primary hyperaldosteronism in hypertensive patients with an aldosterone-to-renin ratio greater than 20. The SHRIMP study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism.European journal of endocrinology · 2025Article
- Captopril challenge test: an underutilized test in the diagnosis of primary aldosteronism.Endocrine connections · 2024Review
- Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism.Journal of human hypertension · 2023Article
- Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.Biomedicines · 2021Review
- Evaluation of Abdominal Computed Tomography Scans for Differentiating the Discrepancies in Abdominal Adipose Tissue Between Two Major Subtypes of Primary Aldosteronism.Frontiers in endocrinology · 2021Article
- Comparison of the shortened and standard saline infusion tests for primary aldosteronism diagnostics.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Serum-soluble (pro)renin receptor concentration as a biomarker for organ damage in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The characteristics of captopril challenge test-positive patients using various criteria.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
- Evaluation of various confirmatory tests for the diagnosis of aldosterone-producing adenoma.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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10 authors.
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Abstract
It remains unknown which surrogate markers can predict diagnostic test results for primary hyperaldosteronism (PA). The Secondary Hypertension Registry Investigation in Mie Prefecture (SHRIMP) study has sequentially and prospectively recruited 128 patients with hypertension with an aldosterone-to-renin ratio (ARR) greater than 20, evaluated the differences among essential hypertension (EHT), idiopathic hyperaldosteronism (IHA), and aldosterone-producing adenoma (APA), and analyzed the predictors for the confirmatory tests. The patients underwent saline-loading, captopril-challenge, and upright furosemide-loading tests. Carotid, renovascular, and cardiac echography, brachial ankle pulse wave velocity (baPWV), endothelial function, nocturnal blood pressure decline, and the apnea hypopnea index were evaluated. Multivariate regression analyses showed that the plasma aldosterone concentration (PAC) at screening was a strong predictor of the saline and captopril test results. The plasma renin activity (PRA) at screening, urine β2-microglobulin, and left ventricular mass index (LVMI) were independent predictors for the captopril test. The estimated saline PAC and captopril 60 and 90 min ARRs predicted by the equations were highly correlated with the real values. The ROC curve analysis showed PAC at screening among each of predictors for the diagnostic tests and PAC after the saline-loading test had the highest diagnostic abilities of APA. Patients with IHA were older and had glucose intolerance and increased U-Alb/gCre and resistive indices. In patients with APA, the levels of U-Alb/gCre and urine β2-microglobulin were increased, and levels of insulin and the HOMA-IR were decreased. In conclusion, our proposed equations may be useful for estimating saline PAC and captopril ARR. Diagnostic predictors may differ for each confirmatory test.
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