ArticleEmerging microbes & infections2018
Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells.
Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Is activated partial thromboplastin time prolongation an independent predictor of bleeding in patients with Kyasanur Forest Disease? A retrospective cohort study from southern India.New microbes and new infections · 2026Article
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- First report of Usutu virus fatal infections in Chilean tinamous (Nothoprocta perdicaria), brahminy starlings (Sturnia pagodarum), and multiple other bird species in zoological gardens and wildlife in the Czech Republic.One health outlook · 2026Article
- Comparative Sequence Analysis of the Envelope Gene of Kyasanur Forest Disease Virus Vaccine Strain With Currently Circulating Field Strains.Advances in virology · 2026Article
- Pathogenicity and virulence of Kyasanur Forest disease: A comprehensive review of an expanding zoonotic threat in southwestern India.Virulence · 2025Review
- Review
- Article
- Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling.Biofabrication · 2024Review
- Development of a clinical scoring system to make a presumptive diagnosis of Kyasanur Forest Disease: a case-control study from South India.Le infezioni in medicina · 2024Article
- Fitness of mCherry Reporter Tick-Borne Encephalitis Virus in Tick Experimental Models.Viruses · 2022Article
- Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural-biological analysis.The Journal of biological chemistry · 2022Article
- A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis.PLoS pathogens · 2021Article
- Analysis of Hemorrhagic Fever With Renal Syndrome Using Wavelet Tools in Mainland China, 2004-2019.Frontiers in public health · 2020Article
- Multiple Lineages of Usutu Virus (Microorganisms · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Kyasanur Forest disease virus (KFDV) is a highly pathogenic tick-borne flavivirus enzootic to India. In humans, KFDV causes a severe febrile disease. In some infected individuals, hemorrhagic manifestations, such as bleeding from the nose and gums and gastrointestinal bleeding with hematemesis and/or blood in the stool, have been reported. However, the mechanisms underlying these hemorrhagic complications remain unknown, and there is no information about the specific target cells for KFDV. We investigated the interaction of KFDV with vascular endothelial cells (ECs) and monocyte-derived dendritic cells (moDCs), which are key targets for several other hemorrhagic viruses. Here, we report that ECs are permissive to KFDV infection, which leads to their activation, as demonstrated by the upregulation of E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 at the mRNA and protein levels. Increased expression of these adhesive molecules correlated with increased leukocyte adhesion. Infected ECs upregulated the expression of interleukin (IL)-6 but not IL-8. Additionally, moDCs were permissive to KFDV infection, leading to increased release of IL-6 and tumor necrosis factor-α. Supernatants from KFDV-infected moDCs caused EC activation, as measured by leukocyte adhesion. The results indicate that ECs and moDCs can be targets for KFDV and that both direct and indirect mechanisms can contribute to EC activation.
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Registered trials
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