Evidence map›Paper›PMID 30401774›Full record

ArticlemBio2018

Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence.

Andrew L Chang, Tamara L Doering

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 62 citations in OpenAlex.

  1. Mitochondrial cardiolipin sequestration of caspofungin underliesbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Peroxisomes regulate virulence and cell density sensing inbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism inInternational journal of molecular sciences · 2025
    Article
  8. Review
  9. Phosphatidylcholine biosynthesis pathways inFrontiers in cellular and infection microbiology · 2025
    Article
  10. Recent innovations and challenges in the treatment of fungal infections.Frontiers in cellular and infection microbiology · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. A fungal protein organizes both glycogen and cell wall glucans.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew L ChangDepartment of Molecular Microbiology, Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, Washington University, St. Louis, Missouri, USA doering@wustl.edu.ORCID 0000-0002-5179-7393
Washington University in St. Louis · US

Funding

HOST FACTORS IN CRYPTOCOCCAL PATHOGENESISR01AI102882 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2013 to 2017
$2.2M
MITOCHONDRIAL REGULATION IN CRYPTOCOCCUS NEOFORMANSR21AI136688 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$429k
NIAID NIH HHS R01 AI102882NIAID NIH HHS R21 AI136688
6 · The paper itself

Abstract

Mitochondria are essential organelles that act in pathways including ATP production, β-oxidation, and clearance of reactive oxygen species. They occur as a complex reticular network that constantly undergoes fusion and fission, mediated by dynamin-related proteins (DRPs). DRPs include Fzo1, which mediates fusion, and Dnm1, Mdv1, and Fis1, which mediate fission. Mitochondrial morphology has been implicated in virulence in multiple fungi, as with the association between virulence and increased mitochondrial fusion in

Indexed as

AnimalsCryptococcosisCryptococcus neoformansDisease Models, AnimalFemaleGene DeletionMacrophagesMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsOxidation-ReductionVirulenceVirulence FactorsMitochondrial ProteinsVirulence FactorsCryptococcus neoformansMitochondriaMitochondrial morphologyPathogenic fungi

Identifiers

PMID30401774
PMCPMC6222134
OpenAlexW2900085572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.