Evidence map›Paper›PMID 30401764›Full record

ArticleGenetics2018

Sentryn and SAD Kinase Link the Guided Transport and Capture of Dense Core Vesicles in

Logan M Morrison, Stacey L Edwards, Laura Manning, Natalia Stec, Janet E Richmond, Kenneth G Miller

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  6. Article
  7. RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Logan M MorrisonGenetic Models of Disease Laboratory, Oklahoma Medical Research Foundation, Oklahoma 73104.
Stacey L EdwardsGenetic Models of Disease Laboratory, Oklahoma Medical Research Foundation, Oklahoma 73104.
Laura ManningDepartment of Biological Sciences, University of Illinois at Chicago, Illinois 60607.
Natalia StecGenetic Models of Disease Laboratory, Oklahoma Medical Research Foundation, Oklahoma 73104.
Janet E RichmondDepartment of Biological Sciences, University of Illinois at Chicago, Illinois 60607.
Kenneth G MillerGenetic Models of Disease Laboratory, Oklahoma Medical Research Foundation, Oklahoma 73104 kmiller2686@gmail.com.
Oklahoma Medical Research Foundation · USUniversity of Illinois Chicago · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Signaling Pathways that Regulate Synaptic TransmissionR01GM080765 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MILLER, KENNETH GEORGE · 2007 to 2015
$2.7M
NIGMS NIH HHS R01 GM080765NIH HHS P40 OD010440
6 · The paper itself

Abstract

Dense core vesicles (DCVs) can transmit signals by releasing neuropeptides from specialized synaptic regions called active zones. DCVs reach the active zone by motorized transport through a long axon. A reverse motor frequently interrupts progress by taking DCVs in the opposite direction. "Guided transport" refers to the mechanism by which outward movements ultimately dominate to bring DCVs to the synaptic region. After guided transport, DCVs alter their interactions with motors and enter a "captured" state. The mechanisms of guided transport and capture of DCVs are unknown. Here, we discovered two proteins that contribute to both processes in

Indexed as

AnimalsAxonsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsDyneinsMutationNerve Tissue ProteinsProtein Serine-Threonine KinasesSecretory VesiclesCaenorhabditis elegans ProteinsDyneinsNerve Tissue ProteinsProtein Serine-Threonine KinasesSentryn protein, C elegansaxonal transportdense core vesicleLiprinSAD kinaseSentryn

Identifiers

PMID30401764
PMCPMC6218223
OpenAlexW2899803561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.