ArticleBlood advances2018
SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.
Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment.Blood vessels, thrombosis & hemostasis · 2026Article
- Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
- Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face.Research square · 2025Article
- Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma.Cancer communications (London, England) · 2025Article
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis.Journal of visualized experiments : JoVE · 2024Article
- Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration.Life (Basel, Switzerland) · 2023Review
- Article
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site.Research and practice in thrombosis and haemostasis · 2023Article
- High-Pressure Freezing Followed by Freeze Substitution: An Optimal Electron Microscope Technique to Study Golgi Apparatus Organization and Membrane Trafficking.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Fast, streamlined fluorescence nanoscopy resolves rearrangements of SNARE and cargo proteins in platelets co-incubated with cancer cells.Journal of nanobiotechnology · 2022Article
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates.Communications biology · 2021Article
- Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape.Platelets · 2021Article
- Super-resolution imaging of platelet-activation process and its quantitative analysis.Scientific reports · 2021Article
- Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis.Platelets · 2021Article
- Use of electron microscopy to study platelets and thrombi.Platelets · 2020Review
- Quantitative method for estimating stain density in electron microscopy of conventionally prepared biological specimens.Journal of microscopy · 2020Article
- 3D ultrastructural analysis of α-granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets.Research and practice in thrombosis and haemostasis · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Platelet α-granule cargo release is fundamental to both hemostasis and thrombosis. Granule matrix hydration is a key regulated step in this process, yet its mechanism is poorly understood. In endothelial cells, there is evidence for 2 modes of cargo release: a jack-in-the-box mechanism of hydration-dependent protein phase transitions and an actin-driven granule constriction/extrusion mechanism. The third alternative considered is a prefusion, channel-mediated granule swelling, analogous to the membrane "ballooning" seen in procoagulant platelets. Using thrombin-stimulated platelets from a set of secretion-deficient, soluble
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