Evidence map›Paper›PMID 30401749›Full record

ArticleThe Journal of biological chemistry2018

Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.

Jiaqi Mi, Erika Hooker, Steven Balog, Hong Zeng, Daniel T Johnson, Yongfeng He, Eun-Jeong Yu, Huiqing Wu, Vien Le, Dong-Hoon Lee and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. eLife · 2023
    Article
  5. Review
  6. Article
  7. Molecular neuropathology of brain-invasive meningiomas.Brain pathology (Zurich, Switzerland) · 2022
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jiaqi MiFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Erika HookerFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010; the Department of Urology and Stanford University School of Medicine, Stanford, California 94305.
Steven BalogFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Hong Zengthe Transgenic, Knockout and Tumor Model Center, Stanford University School of Medicine, Stanford, California 94305, and.
Daniel T Johnsonthe Department of Urology and Stanford University School of Medicine, Stanford, California 94305.
Yongfeng HeFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010; the Department of Urology and Stanford University School of Medicine, Stanford, California 94305.
Eun-Jeong YuFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010; the Department of Urology and Stanford University School of Medicine, Stanford, California 94305.
Huiqing WuPathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Vien LeFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Dong-Hoon LeeFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Joseph AldahlFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010.
Mark L Gonzalgothe Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136.
Zijie SunFrom the Departments of Cancer Biology and Pathology, Beckman Research Institute, City of Hope, Duarte, California 91010; the Department of Urology and Stanford University School of Medicine, Stanford, California 94305. Electronic address: zjsun@coh.org.
City of Hope · USStanford University · USCity Of Hope National Medical Center · USUniversity of Miami · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
Roles of the androgen receptor and its co-regulators in prostate tumorigenesisR01CA070297 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2003 to 2025
$5.0M
Wnt responsive stem cells in the prostateR01DK104941 · NIDDK · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2015 to 2024
$3.0M
A new regulator for Wnt/beta-catenin signaling and prostate tumorigenesisR01CA151623 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2011 to 2015
$1.7M
A New Mechanism for Castration Resistant Prostate CancerR01CA166894 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2015 to 2018
$1.2M
Cellular And Molecular Properties Of PINs In Prostate TumorigenesisR21CA190021 · NCI · STANFORD UNIVERSITY · PI SUN, ZIJIE · 2014 to 2016
$401k
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA070297NCI NIH HHS R01 CA151623NCI NIH HHS R01 CA166894NCI NIH HHS R21 CA190021NIDDK NIH HHS R01 DK104941
6 · The paper itself

Abstract

Emerging evidence has shown that the hepatocyte growth factor (HGF) and its receptor, MET proto-oncogene, receptor tyrosine kinase (MET), promote cell proliferation, motility, morphogenesis, and angiogenesis. Whereas up-regulation of MET expression has been observed in aggressive and metastatic prostate cancer, a clear understanding of MET function in prostate tumorigenesis remains elusive. Here, we developed a conditional

Indexed as

Signal TransductionAnimalsCell Transformation, NeoplasticHepatocyte Growth FactorMaleMiceMice, TransgenicProstatic NeoplasmsProto-Oncogene MasProto-Oncogene Proteins c-metPTEN PhosphohydrolaseHepatocyte Growth FactorHGF protein, mouseMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-metPTEN PhosphohydrolasePten protein, mouseandrogen receptorepithelial-to-mesenchymal transitiongene knockouthepatocyte growth factor/scatter factor (HGF/SF)HGF/SFMetmetastasisPB-Cre4phosphatase and tensin homolog (PTEN)prostate cancerprostatic intraepithelial neoplasiatransgenic micetumor cell biologytumorigenesis

Identifiers

PMID30401749
PMCPMC6311521
OpenAlexW2899943563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.