ArticleAmerican journal of human genetics2018
FUT2 Variants Confer Susceptibility to Familial Otitis Media.
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Article in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Systems perspectives on pediatric otitis media: environmental exposures, genetic susceptibility, and biomarker-guided interventions.Frontiers in pediatrics · 2026Review
- Rare and low-frequency variants in families with otitis media.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction.American journal of respiratory cell and molecular biology · 2025Article
- A NovelInternational journal of molecular sciences · 2025Article
- Identification of rare missense variants in the BSN gene co-segregating with chronic otitis media in a consanguineous Pakistani family.Molecular genetics & genomic medicine · 2024Article
- Otitis Media in Children with Down Syndrome Is Associated with Shifts in the Nasopharyngeal and Middle Ear Microbiotas.Genetic testing and molecular biomarkers · 2023Article
- Detection of c.375A>G, c.385A>T, c.571C>T, andDiagnostics (Basel, Switzerland) · 2023Article
- Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.The European respiratory journal · 2023Article
- Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets.American journal of human genetics · 2023Article
- Estimation of Lewis Blood Group Status by Fluorescence Melting Curve Analysis in Simultaneous Genotyping of c.385A>T and Fusion Gene inDiagnostics (Basel, Switzerland) · 2023Article
- Audiologic Measures in an Indigenous Community withGenetic testing and molecular biomarkers · 2023Article
- Newborn Hearing Screening and Beyond: A Continuing Journey in the Philippines.Acta medica Philippina · 2023Article
- Human Milk Oligosaccharide Compositions Illustrate Global Variations in Early Nutrition.The Journal of nutrition · 2022Article
- Microbiota Associated With Cholesteatoma Tissue in Chronic Suppurative Otitis Media.Frontiers in cellular and infection microbiology · 2022Article
- The role of CDHR3 in susceptibility to otitis media.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Otitis media susceptibility and shifts in the head and neck microbiome due toJournal of medical genetics · 2021Article
- The transcriptional landscape of the cultured murine middle ear epithelium in vitro.Biology open · 2021Article
- Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection.ERJ open research · 2021Article
- TheFrontiers in cellular and infection microbiology · 2021Article
- A Functional Variant Rs492554 Associated With Congenital Heart Defects ModulatesFrontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
61 authors at 18 institutions in 6 countries.
Regie Lyn P Santos-CortezDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Center for Children's Surgery, Children's Hospital Colorado (CHCO), Aurora, CO 80045, USA; Philippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines. Electronic address: regie.santos-cortez@ucdenver.edu.
Charlotte M ChiongPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; National Hearing Screening Reference Center, UP Manila-NIH, Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Daniel N FrankDivision of Infectious Diseases, Department of Medicine, CUSOM, Aurora, CO 80045, USA.
Allen F RyanDivision of Otolaryngology, Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.
Arnaud P J GieseDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Tori Bootpetch RobertsDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Kathleen A DalyDepartment of Otolaryngology, Head and Neck Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Matthew J SteritzDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Wasyl SzeremetaDepartment of Otolaryngology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Melquiadesa PedroPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines.
Harold PineDepartment of Otolaryngology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Talitha Karisse L YarzaPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; National Hearing Screening Reference Center, UP Manila-NIH, Manila 1000, Philippines.
Melissa A ScholesDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Erasmo Gonzalo D V LlanesPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Saira YousafDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Norman FriedmanDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Ma Leah C TantocoPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Todd M WineDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Patrick John LabraDepartment of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Jeanne BenoitDivision of Infectious Diseases, Department of Medicine, CUSOM, Aurora, CO 80045, USA.
Amanda G RuizDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Rhodieleen Anne R de la CruzDepartment of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Christopher GreenleeDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Ayesha YousafInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Punjab, Pakistan.
Jonathan CardwellDepartment of Medicine, CUSOM, Aurora, CO 80045, USA.
Rachelle Marie A NonatoDepartment of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Dylan RayDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Kimberly Mae C OngDepartment of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Edward SoDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Charles E RobertsonDivision of Infectious Diseases, Department of Medicine, CUSOM, Aurora, CO 80045, USA.
Jordyn DinwiddieDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Sheryl Mae Lagrana-VillagraciaPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines.
University of Washington Center for Mendelian Genomics (UWCMG)
Samuel P GubbelsDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Rehan S ShaikhInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Punjab, Pakistan.
Stephen P CassDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Elisabet EinarsdottirFolkhälsan Institute of Genetics and Molecular Neurology Research Program, University of Helsinki, Helsinki 00014, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden.
Nanette R LeeUSC-Office of Population Studies Foundation and Department of Anthropology, Sociology and History, University of San Carlos, Cebu City 6000, Philippines.
David A SchwartzDepartment of Medicine, CUSOM, Aurora, CO 80045, USA.
Teresa Luisa I Gloria-CruzPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Michael J BamshadDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Ivana V YangDepartment of Medicine, CUSOM, Aurora, CO 80045, USA.
Juha KereFolkhälsan Institute of Genetics and Molecular Neurology Research Program, University of Helsinki, Helsinki 00014, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden; Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.
Generoso T AbesPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Jeremy D PragerDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Saima RiazuddinDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Abner L ChanPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines.
Patricia J YoonDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Eva Maria Cutiongco-de la PazUP Manila - NIH, Manila 1000, Philippines; Philippine Genome Center, UP, Quezon City 1101, Philippines.
Sven-Olrik StreubelDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Maria Rina T Reyes-QuintosPhilippine National Ear Institute, University of the Philippines (UP) Manila - National Institutes of Health (NIH), Manila 1000, Philippines; National Hearing Screening Reference Center, UP Manila-NIH, Manila 1000, Philippines; Department of Otorhinolaryngology, UP Manila College of Medicine - Philippine General Hospital, Manila 1000, Philippines; UP Manila - NIH, Manila 1000, Philippines.
Herman A JenkinsDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA.
Petri MattilaDepartment of Otorhinolaryngology, Head & Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS, Finland.
Kenny H ChanDepartment of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, CO 80045, USA; Department of Pediatric Otolaryngology, CHCO, Aurora, CO 80045, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Suzanne M LealCenter for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Lena HafrénDepartment of Otorhinolaryngology, Head & Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS, Finland.
Tasnee ChonmaitreeDepartment of Pediatrics, Division of Infectious Diseases, UTMB, Galveston, TX 77555, USA.
Michele M SaleCenter for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA.
Zubair M AhmedDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
The Medical Center of Aurora · USUniversity of Colorado Denver · USUniversity of the Philippines Manila · PHPhilippine General Hospital · PHUniversity of Maryland, Baltimore · USThe University of Texas Medical Branch at Galveston · USBahauddin Zakariya University · PKHelsinki University Hospital · FIUniversity of Washington · USBaylor College of Medicine · USCenter for Children · USKarolinska Institutet · SEUniversity of California, San Diego · USUniversity of Helsinki · FIUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of San Carlos · PHUniversity of Virginia · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MUW Center for Mendelian GenomicsU54HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, NICKERSON, DEBORAH A · 2012 to 2015
$20.0MRole of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4MUW Center for Mendelian GenomicsUM1HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, LEAL, SUZANNE M · 2016 to 2020
$15.3MGenetic Epidemiology of Body Mass Index, Adiposity and Weight GainR01DK078150 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2007 to 2010
$2.3MOtitis Media Susceptibility and Middle Ear Microbial Shifts due to Gene VariantsR01DC015004 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR · 2016 to 2020
$1.9MObesity development and CVD risk factor--Filipino womenR01HL085144 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S · 2006 to 2009
$1.9MAn Interdisciplinary Strategy for Obesity (RMI)P20RR020649 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2004 to 2006
$1.7MFunctional Genetics in Idiopathic Pulmonary FibrosisR33HL120770 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2016 to 2018
$1.6MEffect of Health on Education &Work in Filipino YouthR01TW005596 · FIC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S · 2001 to 2005
$1.5MWeight, Diet, Genes and CVD Risk Factors (Hypertension and Diabetes)R01TW008288 · FIC · UNIVERSITY OF SAN CARLOS · PI MAYOL, NANETTE LEE · 2009 to 2011
$152kFIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288NCRR NIH HHS P20 RR020649NHGRI NIH HHS U54 HG006493NHGRI NIH HHS UM1 HG006493NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R33 HL120770NIDCD NIH HHS R01 DC015004NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK078150NIEHS NIH HHS P30 ES010126
Abstract
Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154
Indexed as
AnimalsCell LineChlorocebus aethiopsCOS CellsEar, MiddleExomeFemaleFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGenetic VariationHEK293 CellsHumansMaleMiceMice, Inbred C57BLMicrobiotaFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferase16S rRNA sequencingA antigenfucosyltransferaseFUT2microbiomemiddle ear infectionotitis mediaTDTtransient expressiontransmission disequilibrium test
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