Evidence map›Paper›PMID 30401430›Full record

ArticleMolecular cell2018

Liquid and Hydrogel Phases of PrP

Mikhail A Kostylev, Marcus D Tuttle, Suho Lee, Lauren E Klein, Hideyuki Takahashi, Timothy O Cox, Erik C Gunther, Kurt W Zilm, Stephen M Strittmatter

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Upregulated PrPNPJ precision oncology · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Liquid-liquid phase separation in Alzheimer's disease.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  17. Review
  18. Excess PrPNature communications · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mikhail A KostylevCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Marcus D TuttleCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Chemistry, Yale University School of Medicine, New Haven, CT, USA.
Suho LeeCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Lauren E KleinDepartment of Chemistry, Yale University School of Medicine, New Haven, CT, USA.
Hideyuki TakahashiCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Timothy O CoxCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Erik C GuntherCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Kurt W ZilmDepartment of Chemistry, Yale University School of Medicine, New Haven, CT, USA. Electronic address: kurt.zilm@yale.edu.
Stephen M StrittmatterCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA. Electronic address: stephen.strittmatter@yale.edu.
Yale University · US

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Yale Alzheimer Disease Research CenterP50AG047270 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2015 to 2019
$8.3M
Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
Characterizing and Targeting Pyk2 Kinase in Alzheimer’s DiseaseRF1AG053000 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2016 to 2016
$2.1M
NIA NIH HHS P50 AG047270NIA NIH HHS R01 AG034924NIA NIH HHS RF1 AG053000NIGMS NIH HHS T32 GM008283NINDS NIH HHS R35 NS097283
6 · The paper itself

Abstract

Protein phase separation by low-complexity, intrinsically disordered domains generates membraneless organelles and links to neurodegeneration. Cellular prion protein (PrP

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCell LineCell MembraneChlorocebus aethiopsCOS CellsHEK293 CellsHumansHydrogelsMagnetic Resonance ImagingMolecular ConformationNeuronsPrionsProtein BindingAmyloid beta-PeptidesHydrogelsPrionsPrPC ProteinsReceptor, Metabotropic Glutamate 5

Identifiers

PMID30401430
PMCPMC6226277
OpenAlexW2898416998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.