Evidence map›Paper›PMID 30400981›Full record

ReviewWorld journal of surgical oncology2018

Progress in research on the role of circular RNAs in lung cancer.

Yang Chen, Shuzhen Wei, Xiyong Wang, Xiaoli Zhu, Shuhua Han

Open access · goldAbstract readReview
In one paragraph

Review in World journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Non-Coding RNAs as Key Regulators in Lung Cancer.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. CircRNA: A novel potential strategy to treat thyroid cancer (Review).International journal of molecular medicine · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yang ChenMedical School of Southeast University, Nanjing, China.
Shuzhen WeiDepartment of Respiratory, Zhongda Hospital, Southeast University, Nanjing, China.
Xiyong WangMedical School of Southeast University, Nanjing, China.
Xiaoli ZhuDepartment of Respiratory, Zhongda Hospital, Southeast University, Nanjing, China.
Shuhua HanDepartment of Respiratory, Zhongda Hospital, Southeast University, Nanjing, China. hanshuhua0922@126.com.
Southeast University · CNZhongda Hospital Southeast University · CN

Funding

Nanjing Medical Science and Technology Development Project YKK16257Postgraduate Research & Practice Innovation Program of Jiangsu Province, China no. SJZZ16_0042
6 · The paper itself

Abstract

backgroundCircular RNA (circRNA), as a covalently closed circular RNA molecule, is widely present, which is recognized as a competing endogenous RNA. A large number of differentially expressed circRNAs have been identified and are recognized as potential biomarkers for the diagnosis of tumors. MAIN BODY: CircRNAs play an important role in the regulation of cell signaling pathways. The main biological functions of circRNAs include acting as miRNA sponges, regulating the transcription of the parental genes, and acting as adapters to regulate the interactions between proteins and encoding proteins. Compared with normal tissues, there are differentially expressed circRNAs in lung cancer tissue, and the expression levels of circRNAs are correlated with clinicopathological features of lung cancer. Their roles in pathway regulation are described, and the diagnostic and prognostic values are further evaluated.

conclusionIn lung cancer, circRNAs participate in the proliferation, migration, and invasion, acting as a competitive endogenous RNA. Differentially expressed circRNAs may serve as non-invasive diagnostic markers for lung cancers. Further investigation of the roles of circRNAs in the pathogenesis and regulatory pathways is conducive to the development of novel approaches for the diagnosis and accurate treatment of lung cancers.

Indexed as

Biomedical ResearchHumansLung NeoplasmsPrognosisRNARNA, CircularRNARNA, CircularBiological diagnosisBiomarkerCircular RNAEndogenous regulationLung cancer

Identifiers

PMID30400981
PMCPMC6220476
OpenAlexW2900211312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.