ReviewArthritis research & therapy2018
The inflammatory response in the regression of lumbar disc herniation.
Review in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it, 220 citations in OpenAlex.
- Application and mechanism of percutaneous puncture disc platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Traditional Chinese exercises on pain and disability in middle-aged and elderly patients with lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- Minimally invasive versus open transforaminal lumbar interbody fusion for single segmental lumbar disc herniation: A meta-analysis.Journal of back and musculoskeletal rehabilitation · 2022Pooled it
- Eight Surgical Interventions for Lumbar Disc Herniation: A Network Meta-Analysis on Complications.Frontiers in surgery · 2021Pooled it
- Efficacy and Safety of CT-Verified Deep Needling at the Foramen Acupoint for Lumbar Disc Herniation: A Randomized Controlled Trial.Pain research & management · 2026Trial
- Sustained versus repetitive standing trunk extension results in greater spinal growth and pain improvement in back pain:A randomized clinical trial.Journal of back and musculoskeletal rehabilitation · 2024Trial
- A comparison between transforaminal lumbar epidural injection performed under picture archiving and communication systems-based magnetic resonance imaging planning and injection under immediate X-ray guidance.Joint diseases and related surgery · 2024Trial
- Effect of Nonsurgical Spinal Decompression on Intensity of Pain and Herniated Disc Volume in Subacute Lumbar Herniated Disc.International journal of clinical practice · 2022Trial
- Dermatome-Specific Herpes Zoster Following Corticosteroid Therapy for Lumbar Disc Herniation: A Case Report Illustrating the Immunocompromised District Theory.Clinical case reports · 2026Article
- Revealing the Dynamic Association Between Lymphatic Endothelial Cell Markers and Intervertebral Disk Degeneration.Biomedicines · 2026Article
- Synergetic mechanism by decompression and bone bioactive factors to induce the spontaneous resolution of lumbar disc herniation.Scientific reports · 2026Article
- The influence of decorin, a potential pro-inflammatory stimulant, on the mechanical properties of the annulus fibrosus.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Review
- From Protrusion to Extrusion: Reassessing the Selective Role of Intradiscal Interventions.Anesthesiology and pain medicine · 2026Review
- Integrated machine learning and multi-omics analysis identifies CYP1B1 as a candidate target of orientin in intervertebral disc degeneration-associated low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Predictive Factors for Resorption in Lumbar Disc Herniation: A Systematic Review.Journal of inflammation research · 2026Review
- Efficacy of Governor Vessel-Based Acupuncture, Alone or in Combination with Other Therapies, for Acute Lumbar Disc Herniation: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
- Data-driven serum cytokine and chemokine phenotypes are associated with MRI-defined disc regression and persistent radicular pain in lumbar disc herniation.Frontiers in immunology · 2026Observational
- Lumbar Disc Herniation Resorption: When and How Does It Occur?Neurospine · 2026Review
- M2a macrophages identified as a potential therapeutic candidate for intervertebral disc herniation regression.Osteoarthritis and cartilage open · 2025Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, inflammation has also been indicated as the main factor responsible for LDH regression. This apparent controversy places inflammation as a good prognostic indicator of spontaneous regression of LDH. This review addresses the molecular and cellular mechanisms involved in LDH regression, including matrix remodeling and neovascularization, in the scope of the clinical decision on conservative versus surgical intervention. Based on the evidence, a special focus on the inflammatory response in the LDH context is given, particularly in the monocyte/macrophage role. The phenomenon of spontaneous regression of LDH, extensively reported in the literature, is therefore analyzed here under the perspective of the modulatory role of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.