Evidence map›Paper›PMID 30400876›Full record

Trial reportBMC neurology2018

Pragmatic trial of multifaceted intervention (STROKE-CARD care) to reduce cardiovascular risk and improve quality-of-life after ischaemic stroke and transient ischaemic attack -study protocol.

Thomas Toell, Christian Boehme, Lukas Mayer, Stefan Krebs, Clemens Lang, Karin Willeit, Barbara Prantl, Michael Knoflach, Gerhard Rumpold, Gudrun Schoenherr and 6 more

3 registry-linked trialsOpen access · goldAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02156778 nacompletednot on this map

Multifaceted Intervention to Reduce Recurrent Cardiovascular Events and Improve Quality-of-Life After Ischemic Stroke and High-Risk Transient Ischemic Attack (TIA)

TypeinterventionalSponsorMedical University InnsbruckRan2014 to 2019Enrolled2,149ConditionsStroke, Ischemic Attack, Transient, Secondary Prevention, Disease ManagementArmsActive Comparator: Extended Standard Care (Stroke Card), Active Comparator: Standard Care
NCT04205006 unknown statusnot on this mapstarted 2019, after this paper: background citation

Long-term Outcome of a Pragmatic Trial of Multifaceted Intervention (STROKE-CARD Care) to Reduce Cardiovascular Risk and Improve Quality-of-life After Ischemic Stroke and Transient Ischemic Attack

TypeobservationalSponsorMedical University InnsbruckRan2019 to 2022Enrolled1,000ConditionsIschemic Stroke, TIA
NCT04582825 active not recruitingnot on this mapstarted 2020, after this paper: background citation

STROKE-CARD REGISTRY: Extension of Standard Care in Patients With Ischemic Stroke and Transient Ischemic Attack

Typeobservational_patient_registrySponsorVASCage GmbHRan2020 to 2027Enrolled5,000ConditionsIschemic Stroke, Transient Ischemic AttackArmsN/A - Observational Study
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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  18. [Use of smartphone apps in secondary stroke prevention].Wiener medizinische Wochenschrift (1946) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Thomas ToellDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Christian BoehmeDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Lukas MayerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Stefan KrebsDepartment of Neurology, Hospital St. John of God, Johannes von Gott Platz 1, A-1020, Vienna, Austria.
Clemens LangDepartment of Neurology, Hospital St. John of God, Johannes von Gott Platz 1, A-1020, Vienna, Austria.
Karin WilleitDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Barbara PrantlDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Michael KnoflachDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Gerhard RumpoldDepartment of Medical Psychology, Medical University of Innsbruck, Schöpfstraße 23a, A-6020, Innsbruck, Austria.
Gudrun SchoenherrDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Andrea GriesmacherCentral Institute of Medical and Chemical Laboratory Diagnostics, University Hospital of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Peter WilleitDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria.
Julia FerrariDepartment of Neurology, Hospital St. John of God, Johannes von Gott Platz 1, A-1020, Vienna, Austria.
Wilfried LangDepartment of Neurology, Hospital St. John of God, Johannes von Gott Platz 1, A-1020, Vienna, Austria.
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria. stefan.kiechl@i-med.ac.at.
Johann WilleitDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, A-6020, Innsbruck, Austria. johann.willeit@i-med.ac.at.ORCID http://orcid.org/0000-0003-4083-0466
Innsbruck Medical University · ATHospital of the Brothers of St. John of God · ATSigmund Freud Privatuniversität Wien · ATUniversity Hospital Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of future cardiovascular events. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap exists between risk factor management in real life and that recommended by international guidelines. Moreover, stroke is a leading cause of disability and morbidity which partly emerges from post-stroke complications. METHODS/

designWe designed a block-randomised (2:1 ratio) open pragmatic trial [NCT02156778] with blinded outcome assessment comparing STROKE-CARD to usual post-stroke-patient care. STROKE-CARD is a multifaceted post-stroke disease management program with the objective of reducing recurrent cardiovascular events and improving quality of life in ischaemic stroke and TIA-patients. It combines intensified multi-domain secondary prevention, systematic detection and treatment of post-stroke complications, and patient self-empowerment. Enrolment of 2160 patients with acute ischaemic stroke or TIA (ABCD2-Score ≥ 3) is planned at two study centres in Austria. The co-primary efficacy endpoints are (i) the composite of major recurrent cardiovascular events (nonfatal stroke, nonfatal myocardial infarction, and vascular death) occurring within 12 months after the index event and (ii) one-year health-related quality-of-life measured with the European Quality of Life-5 Dimensions (EQ-5D-3 L) questionaire. Secondary endpoints include all-cause mortality, functional outcome, and target-level achievement in risk factor management. DISCUSSION: This trial will provide evidence on whether the pragmatic post-stroke intervention program STROKE-CARD can help prevent cardiovascular events and improve quality-of-life within the setting of a high-quality acute stroke care system. In case of success, STROKE-CARD may be implemented in daily clinical routine and serve as a model for other disease management initiatives.

trial registrationClinicalTrials.gov: NCT02156778 . (June 5, 2014, retrospectively registered).

Indexed as

AustriaCardiovascular DiseasesFemaleHumansIschemic Attack, TransientMaleMyocardial InfarctionOutcome Assessment, Health CareQuality of LifeRetrospective StudiesRisk FactorsSecondary PreventionStrokeDisease managementSecondary preventionStrokeTransient ischemic attack

Identifiers

PMID30400876
PMCPMC6219064
OpenAlexW2899549105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.