Observational studyBMC nephrology2018
Lack of impact of iodinated contrast media on kidney cell-cycle arrest biomarkers in critically ill patients.
Observational study in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- [Biomarkers of oxidative stress and inflammation in contrast-associated acute kidney injury].Anales del sistema sanitario de Navarra · 2024Article
- Article
- Acute kidney injury in neurocritical patients: a retrospective cohort study.International urology and nephrology · 2023Article
- Kidney Cell Cycle Arrest and Cardiac Biomarkers and Acute Kidney Injury Following Angiography: The Prevention of Serious Adverse Events Following Angiography (PRESERVE) Study.Kidney medicine · 2023Article
- Contrast associated nephropathy after intravenous administration: what is the magnitude of the problem?Renal failure · 2021Review
- Acute kidney injury in the critically ill: an updated review on pathophysiology and management.Intensive care medicine · 2021Review
- Iodinated contrast medium: Is there a re(n)al problem? A clinical vignette-based review.Critical care (London, England) · 2020Review
- Investigation of Various Intramuscular Volumes Delivered to the Semimembranosus Muscle ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIodinated contrast media may contribute to acute kidney injury. However, several recent works suggest that this toxicity is minimal in the clinical setting. Recently, urinary G1 cell-cycle arrest proteins tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin like growth factor binding protein 7 (IGFBP-7) were identified as highly sensitive and specific biomarkers for early detection of kidney aggression. The impact of contrast administration on those biomarkers has not been specifically evaluated but could provide clues about the toxicity of contrast media. This study aimed at measuring changes in TIMP-2 and IGFBP-7 urinary concentrations before and after a contrast-enhanced computed tomography in critically ill patients.
methods77 patients were included in a prospective observational cohort study. Urinary [TIMP -2]·[IGFBP-7] was measured before, 6 and 24 h after contrast infusion. Urine output and serum creatinine were followed 3 days.
resultsMedian [TIMP-2]·[IGFBP-7] was 0.06 [interquartile range 0.04;0.26], 0.07 [0.03;0.34] and 0.10 [0.04;0.37] (ng/mL)
conclusionsChanges in [TIMP-2]·[IGFBP-7] urinary concentration after contrast-enhanced computed tomography were insignificant, suggesting minimal kidney aggression by modern iodinated contrast media.
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