ArticleBMC plant biology2018
Global dissection of alternative splicing uncovers transcriptional diversity in tissues and associates with the flavonoid pathway in tea plant (Camellia sinensis).
Article in BMC plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Light-Dependent Temporal Reprogramming of Alternative Splicing Dynamics Under Salt Stress in Sweet Potato (Plants (Basel, Switzerland) · 2026Article
- Genome-wide identification of the AP2/ERF gene family and its alternative splicing to reveal their expression profiles in different tissues of Rosa roxburghii.BMC plant biology · 2026Article
- Pre-mRNA splicing and its regulation in microalgae and cyanobacteria.Advanced biotechnology · 2025Review
- Comprehensive analysis of alternative splicing inFrontiers in plant science · 2025Article
- Importance of pre-mRNA splicing and its study tools in plants.Advanced biotechnology · 2024Review
- A geraniol synthase regulates plant defense via alternative splicing in tea plants.Horticulture research · 2023Article
- Genome-wide identification of the PYL gene family of tea plants (Camellia sinensis) revealed its expression profiles under different stress and tissues.BMC genomics · 2023Article
- Comprehensive analysis of the laccase gene family in tea plant highlights its roles in development and stress responses.BMC plant biology · 2023Article
- Alternative Splicing and Its Roles in Plant Metabolism.International journal of molecular sciences · 2022Review
- Expression and functional analysis ofFrontiers in plant science · 2022Article
- A novel adenylate isopentenyltransferase 5 regulates shoot branching via the ATTTA motif in Camellia sinensis.BMC plant biology · 2021Article
- Intron-retained radish (Raphanus sativus L.) RsMYB1 transcripts found in colored-taproot lines enhance anthocyanin accumulation in transgenic Arabidopsis plants.Plant cell reports · 2021Article
- TeaAS: a comprehensive database for alternative splicing in tea plants (Camellia sinensis).BMC plant biology · 2021Article
- Genome-Wide Investigation of N6-Methyladenosine Regulatory Genes and Their Roles in Tea (Frontiers in plant science · 2021Article
- Alternative Splicing During theG3 (Bethesda, Md.) · 2020Article
- Article
- Alternative Splicing Regulation of Anthocyanin Biosynthesis inG3 (Bethesda, Md.) · 2020Article
- Comprehensive profiling of alternative splicing landscape during cold acclimation in tea plant.BMC genomics · 2020Article
- Identification and distribution of a single nucleotide polymorphism responsible for the catechin content in tea plants.Horticulture research · 2020Article
- Genome-wide profiling of alternative splicing genes in hybrid poplar (P.alba×P.glandulosa cv.84K) leaves.PloS one · 2020Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAlternative splicing (AS) regulates mRNA at the post-transcriptional level to change gene function in organisms. However, little is known about the AS and its roles in tea plant (Camellia sinensis), widely cultivated for making a popular beverage tea.
resultsIn our study, the AS landscape and dynamics were characterized in eight tissues (bud, young leaf, summer mature leaf, winter old leaf, stem, root, flower, fruit) of tea plant by Illumina RNA-Seq and confirmed by Iso-Seq. The most abundant AS (~ 20%) was intron retention and involved in RNA processes. The some alternative splicings were found to be tissue specific in stem and root etc. Thirteen co-expressed modules of AS transcripts were identified, which revealed a similar pattern between the bud and young leaves as well as a distinct pattern between seasons. AS events of structural genes including anthocyanidin reductase and MYB transcription factors were involved in biosynthesis of flavonoid, especially in vegetative tissues. The AS isoforms rather than the full-length ones were the major transcripts involved in flavonoid synthesis pathway, and is positively correlated with the catechins content conferring the tea taste. We propose that the AS is an important functional mechanism in regulating flavonoid metabolites.
conclusionOur study provides the insight into the AS events underlying tea plant's uniquely different developmental process and highlights the important contribution and efficacy of alternative splicing regulatory function to biosynthesis of flavonoids.
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