Evidence map›Paper›PMID 30400793›Full record

ArticleBMC veterinary research2018

Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats.

Henning Richter, Agnieszka Karol, Katja Nuss, Aymone Lenisa, Erika Bruellmann, Stella-Saphira Maudens, Heinrich Hoffmann, Brigitte von Rechenberg, Patrick R Kircher

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Henning RichterClinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland. henning.richter@uzh.ch.ORCID http://orcid.org/0000-0003-3696-6993
Agnieszka KarolMusculoskeletal Research Unit, Zurich, Switzerland.
Katja NussMusculoskeletal Research Unit, Zurich, Switzerland.
Aymone LenisaMusculoskeletal Research Unit, Zurich, Switzerland.
Erika BruellmannPhilips AG, Allmendstrasse 140, 8027, Zürich, Switzerland.
Stella-Saphira MaudensPowder Technology Lab, IMX_LTP, Station 12, MXD 340, EPFL, 1015, Lausanne, Switzerland.
Heinrich HoffmannPowder Technology Lab, IMX_LTP, Station 12, MXD 340, EPFL, 1015, Lausanne, Switzerland.
Brigitte von RechenbergMusculoskeletal Research Unit, Zurich, Switzerland.
Patrick R KircherClinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
University of Zurich · CHÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Nano-Tera.ch Magnetotheranostics, project N°530 627
6 · The paper itself

Abstract

backgroundObjective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model (MatLyLu) in 12 Copenhagen rats. Two groups (n = 6) of animals were inoculated with 1 × 10

resultsBoth types of injection were able to induce the adenocarcinoma model using MatLyLu tumor cells. The primary tumor could be visualized in MRI and confirmed histologically. Comparing the risk of reflux and the maximum injection volume during injection, the hock injection was superior to the footpad injection (less reflux, less anatomical restrictions for larger volumes). The hock injection induces a faster tumor growth compared to the footpad injection. As consequence the maximum level of long term discomfort after hock injection was reached earlier, even if it grew on a not weight bearing structure. Early lymph node tumor metastasis could not be observed macroscopically nor detected histologically. Therefore the reproducibility of the MatLyLu tumor model is questionable.

conclusionHock injection is a feasible alternative technique compared with footpad-injection in rats. It provides a save and easy injection method for various early-terminated applications with the potential to increase animal welfare during tumor models in rats.

Indexed as

Disease Models, AnimalFootTarsus, AnimalAdenocarcinomaAnimalsFemaleInjectionsMagnetic Resonance ImagingMaleNeoplasm TransplantationProstatic NeoplasmsRats3RCopenhagen ratFootpad injectionHock injectionMatLyLuTumor model

Identifiers

PMID30400793
PMCPMC6219108
OpenAlexW2900260985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.