Evidence map›Paper›PMID 30400783›Full record

ArticleBMC cancer2018

Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study.

Eunjung Lee, Jianning Luo, Fredrick R Schumacher, David Van Den Berg, Anna H Wu, Daniel O Stram, Leslie Bernstein, Giske Ursin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA. leee@usc.edu.ORCID http://orcid.org/0000-0002-8287-6131
Jianning LuoDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.
Giske UrsinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.
University of Southern California · USCity of Hope · USCase Western Reserve University · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
USC CANCER EPIDEMIOLOGY &BIOSTATISTICS UNITP01CA017054 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STRAM, DANIEL O · 1985 to 2009
$18.2M
Research and Mentoring on Energetic Factors and Cancer: Established InvestigatorK05CA136967 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BERNSTEIN, LESLIE · 2009 to 2013
$684k
National Cancer Institute K05 CA136967National Cancer Institute P01 CA017054National Cancer Institute R01 CA77398NCI NIH HHS K05 CA136967NCI NIH HHS P01 CA017054NCI NIH HHS R01 CA077398NIEHS NIH HHS P30 ES007048Susan G. Komen CCR15333900
6 · The paper itself

Abstract

backgroundThe contribution of genetic polymorphisms to the large inter-individual variation in mammographic density (MD) changes following starting and stopping use of estrogen and progestin combined therapy (EPT) has not been well-studied. Previous studies have shown that circulating levels of insulin-like growth factors are associated with MD and cross-talk between estrogen signaling and growth factors is necessary for cell proliferation in the breast. We evaluated single nucleotide polymorphisms (SNPs) in growth factor genes in association with MD changes after women stop EPT use.

methodsWe genotyped 191 SNPs in 13 growth factor pathway genes in 284 non-Hispanic white California Teachers Study participants who previously used EPT and collected their mammograms before and after quitting EPT. Percent MD was assessed using a computer-assisted method. Change in percent MD was calculated by subtracting percent MD of an 'off-EPT' mammogram from percent MD of an 'on-EPT' (i.e. baseline) mammogram. We used multivariable linear regression analysis to investigate the association between SNPs and change in percent MD. We calculated P-values corrected for multiple testing within a gene (P

resultsRs1983210 in INHA and rs35539615 in IGFBP1/3 showed the strongest associations. Per minor allele of rs1983210, the absolute change in percent MD after stopping EPT use decreased by 1.80% (a difference in absolute change in percent MD) (P

conclusionsGenetic variation in growth factor pathway genes INHA and IGFBP1/3 may predict longitudinal MD change after women quit EPT. The observed differences in EPT-associated changes in percent MD in association with these genetic polymorphisms are modest but may be clinically significant considering that the magnitude of absolute increase in percent MD reported from large clinical trials of EPT ranged from 3% to 7%.

Indexed as

AdultAllelesBreast DensityBreast NeoplasmsCaliforniaEstrogen Replacement TherapyEstrogensFemaleGenetic Association StudiesGenotypeHumansInhibinsInsulin-Like Growth Factor Binding Protein 1Intercellular Signaling Peptides and ProteinsLongitudinal StudiesMammographyEstrogensIGFBP1 protein, humaninhibin-alpha subunitInhibinsInsulin-Like Growth Factor Binding Protein 1Intercellular Signaling Peptides and ProteinsProgestinsGrowth factor pathwayHormone therapyMammographic densityPolymorphisms

Identifiers

PMID30400783
PMCPMC6220514
OpenAlexW2900276971

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.