Evidence map›Paper›PMID 30400774›Full record

ArticleBMC cardiovascular disorders2018

Trial of exercise to prevent HypeRtension in young adults (TEPHRA) a randomized controlled trial: study protocol.

Wilby Williamson, Odaro J Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02723552 (Trial of Exercise to Prevent HypeRtension in Young Adults), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02723552 nacompletednot on this map

Trial of Exercise to Prevent HypeRtension in Young Adults

TypeinterventionalSponsorUniversity of OxfordRan2016 to 2019Enrolled203ConditionsHypertension, Premature BirthArmsAerobic Exercise
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Wilby WilliamsonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK. wilby.williamson@cardiov.ox.ac.uk.ORCID 0000-0003-2405-1323
Odaro J HuckstepOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Eleni FrangouCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Afifah MohamedOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Cheryl TanOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Maryam AlsharqiOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Mariane BertagnolliOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Winok LapidaireOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Julia NewtonNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Henner HanssenDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Richard McManusNuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.
Helen DawesFaculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
Charlie FosterSchool of Policy Studies, University of Bristol, Bristol, UK.
Adam J LewandowskiOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Paul LeesonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
John Radcliffe Hospital · GBNuffield Orthopaedic Centre · GBOxford Brookes University · GBUniversity of Basel · CHUniversity of Bristol · GBUniversity of Oxford · GB

Funding

British Heart Foundation FS/18/3/33292British Heart Foundation PG/13/58/30397British Heart Foundation PG/17/13/32860Department of Health NIHR-RP-02-12-015Wellcome TrustWellcome Trust 105741/Z/14/Z
6 · The paper itself

Abstract

backgroundHypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to effectively manage young adult hypertension with recommendation to target lifestyle intervention. Surprisingly, no trials have investigated whether lifestyle advice developed for blood pressure control in older adults is effective in these younger populations. METHODS/

designTEPHRA is an open label, parallel arm, randomised controlled trial in young adults with high normal and elevated blood pressure. The study will compare a supervised physical activity intervention consisting of 16 weeks structured exercise, physical activity self-monitoring and motivational coaching with a control group receiving usual care/minimal intervention. Two hundred young adults aged 18-35 years, including a subgroup of preterm born participants will be recruited through open recruitment and direct invitation. Participants will be randomised in a ratio of 1:1 to either the exercise intervention group or control group. Primary outcome will be ambulatory blood pressure monitoring at 16 weeks with measure of sustained effect at 12 months. Study measures include multimodal cardiovascular assessments; peripheral vascular measures, blood sampling, microvascular assessment, echocardiography, objective physical activity monitoring and a subgroup will complete multi-organ magnetic resonance imaging. DISCUSSION: The results of this trial will deliver a novel, randomised control trial that reports the effect of physical activity intervention on blood pressure integrated with detailed cardiovascular phenotyping in young adults. The results will support the development of future research and expand the evidence-based management of blood pressure in young adult populations.

trial registrationClinicaltrials.gov registration number NCT02723552 , registered on 30 March, 2016.

Indexed as

Blood PressureHealthy LifestyleAdolescentAdultAge of OnsetBlood Pressure Monitoring, AmbulatoryEchocardiographyEnglandExercise TherapyFemaleHealth StatusHumansHypertensionMagnetic Resonance ImagingMaleProspective StudiesBlood pressureCardiac imagingCardiac RemodellingCerebrovascular healthExerciseHypertensionPrehypertensionPreterm birthRandomised trialYoung adult

Identifiers

PMID30400774
PMCPMC6220491
OpenAlexW2900315429

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.