Evidence map›Paper›PMID 30400594›Full record

ReviewJournal of clinical medicine2018

Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases.

Giorgina B Piccoli, Elena Zakharova, Rossella Attini, Margarita Ibarra Hernandez, Alejandra Orozco Guillien, Mona Alrukhaimi, Zhi-Hong Liu, Gloria Ashuntantang, Bianca Covella, Gianfranca Cabiddu and 3 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05793346 (Pregnancy-associated Progression of Chronic Kidney Disease), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05793346 unknown statusnot on this mapstarted 2023, after this paper: background citation

Pregnancy-associated Progression of Chronic Kidney Disease: A Study Protocol for the Development and Validation of a Clinical Predictive Tool

TypeobservationalSponsorKing's College LondonRan2023 to 2023Enrolled5,000ConditionsChronic Kidney Diseases, Pregnancy Related
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pregnancy and Long-Term Kidney Function in CKD: A Systematic Review and Meta-Analysis.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  9. [Resilience is job satisfaction using nephrology as an example].Innere Medizin (Heidelberg, Germany) · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Adding creatinine to routine pregnancy tests: a decision tree for calculating the cost of identifying patients with CKD in pregnancy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  20. [Outcome of neonates born to mothers with chronic kidney disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 9 countries.

Giorgina B PiccoliDepartment of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy. gbpiccoli@yahoo.it.ORCID 0000-0002-2632-4009
Elena ZakharovaNephrology, Moscow City Hospital n.a. S.P. Botkin, 101000 Moscow, Russia. helena.zakharova@gmail.com.
Rossella AttiniObstetrics, Department of Surgery, University of Torino, 10100 Torino, Italy. rossella.attini@gmail.com.
Margarita Ibarra HernandezNephrology Service, Hospital Civil de Guadalajara "Fray Antonio Alcalde", University of Guadalajara Health Sciences Center, Guadalajara, Jal 44100, Mexico. maribaher@yahoo.es.
Alejandra Orozco GuillienInstituto Nacional de Perinatologia, Mexico D.F. 01020, Mexico. ale_gaba@hotmail.com.
Mona AlrukhaimiDepartment of Medicine, Dubai Medical College, P.O. Box 20170, Dubai, UAE. mona_539@yahoo.co.uk.
Zhi-Hong LiuNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210000, China. zhihong--liu@hotmail.com.
Gloria AshuntantangYaounde General Hospital & Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 337, Yaounde, Cameroon. maglo09@hotmail.com.
Bianca CovellaNéphrologie, Centre Hospitalier Le Mans, 72000 Le Mans, France. biancacovella@gmail.com.
Gianfranca CabidduNefrologia Ospedale Brotzu, 09100 Cagliari, Italy. gianfranca.cabiddu@tin.it.ORCID 0000-0003-1145-7404
Philip Kam Tao LiPrince of Wales Hospital, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong. philipli@cuhk.edu.hk.
Guillermo Garcia-GarciaNephrology Service, Hospital Civil de Guadalajara "Fray Antonio Alcalde", University of Guadalajara Health Sciences Center, Guadalajara, Jal 44100, Mexico. ggarcia1952@gmail.com.ORCID 0000-0003-0558-0035
Adeera LevinDepartment of Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. alevin@providencehealth.bc.ca.
Centre Hospitalier du Mans · FRHospital Civil de Guadalajara · MXAzienda Ospedaliera G. Brotzu · ITChinese University of Hong Kong · HKDubai Medical College · AEInstituto Nacional de Perinatología · MXMoscow State University of Medicine and Dentistry · RUNanjing General Hospital of Nanjing Military Command · CNProvidence Health Care · CATorino e-district · ITUniversité de Yaoundé I · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy is possible in all phases of chronic kidney disease (CKD), but its management may be difficult and the outcomes are not the same as in the overall population. The prevalence of CKD in pregnancy is estimated at about 3%, as high as that of pre-eclampsia (PE), a better-acknowledged risk for adverse pregnancy outcomes. When CKD is known, pregnancy should be considered as high risk and followed accordingly; furthermore, since CKD is often asymptomatic, pregnant women should be screened for the presence of CKD, allowing better management of pregnancy, and timely treatment after pregnancy. The differential diagnosis between CKD and PE is sometimes difficult, but making it may be important for pregnancy management. Pregnancy is possible, even if at high risk for complications, including preterm delivery and intrauterine growth restriction, superimposed PE, and pregnancy-induced hypertension. Results in all phases are strictly dependent upon the socio-sanitary system and the availability of renal and obstetric care and, especially for preterm children, of intensive care units. Women on dialysis should be aware of the possibility of conceiving and having a successful pregnancy, and intensive dialysis (up to daily, long-hours dialysis) is the clinical choice allowing the best results. Such a choice may, however, need adaptation where access to dialysis is limited or distances are prohibitive. After kidney transplantation, pregnancies should be followed up with great attention, to minimize the risks for mother, child, and for the graft. A research agenda supporting international comparisons is highly needed to ameliorate or provide knowledge on specific kidney diseases and to develop context-adapted treatment strategies to improve pregnancy outcomes in CKD women.

Indexed as

chronic kidney disease (CKD), dialysiskidney transplantationpregnancypregnancy complications

Identifiers

PMID30400594
PMCPMC6262338
OpenAlexW2900260128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.