ArticleInternational journal of molecular sciences2018
Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review.Cellular and molecular neurobiology · 2023Pooled it
- KREO Prevents CUMS-Induced Depressive-Like Behavior via Modulation of the BDNF Signaling Pathway.Food science & nutrition · 2026Article
- Dynamic Environmental Interactions Shape the Volatile Compounds of Agarwood Oils Extracted fromMolecules (Basel, Switzerland) · 2025Article
- Antidepressant Activity of Agarwood Essential Oil: A Mechanistic Study on Inflammatory and Neuroprotective Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Impact of comorbid depression on quality of life and disease progression in chronic obstructive pulmonary disease: a correlational analysis.Frontiers in psychiatry · 2025Article
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- Dynamics of Physiological Properties and Endophytic Fungal Communities in the Xylem ofJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative Analysis of Metabolome and Transcriptome in Different Tissue Sites ofMolecules (Basel, Switzerland) · 2024Article
- Solid-Phase Microextraction/Gas Chromatography-Time-of-Flight Mass Spectrometry Approach Combined with Network Pharmacology Analysis to Evaluate the Quality of Agarwood from Different Regions against Anxiety Disorder.Molecules (Basel, Switzerland) · 2024Article
- Pharmacology and therapeutic potential of agarwood and agarwood tree leaves in periodontitis.Frontiers in pharmacology · 2024Review
- Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.CNS neuroscience & therapeutics · 2023Article
- Effect of Karas (Tropical life sciences research · 2023Article
- Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu/GABA system homeostasis.Biomedical reports · 2023Article
- Chemical Composition and Potential Properties in Mental Illness (Anxiety, Depression and Insomnia) of Agarwood Essential Oil: A Review.Molecules (Basel, Switzerland) · 2022Review
- The potential mechanism of Bupleurum against anxiety was predicted by network pharmacology study and molecular docking.Metabolic brain disease · 2022Article
- Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases.Molecules (Basel, Switzerland) · 2022Review
- Relationships between the changes in sleep patterns and sleep quality among Chinese people during the 2019 coronavirus disease outbreak.Sleep medicine · 2022Article
- Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder.Frontiers in pharmacology · 2022Review
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
In our previous investigation, we found that agarwood essential oil (AEO) has a sedative-hypnotic effect. Sedative-hypnotic drugs usually have an anxiolytic effect, where concomitant anxiety and depression are a common comorbidity. Therefore, this study further investigated the anxiolytic and antidepressant effects of AEO using a series of animal behavior tests on a restraint stress-induced mice model. The elevated plus maze (EPM) test, the light dark exploration (LDE) test, and the open field (OF) test demonstrated that AEO has a significant anxiolytic effect. Simultaneously, the tail suspension (TS) test and the forced swimming (FS) test illuminated that AEO has an antidepressant effect with the immobility time decreased. Stress can cause cytokine and nitric oxide (NO) elevation, and further lead to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. AEO was shown to dose-dependently inhibit the levels of cytokines, including interleukin 1α (IL-1α), IL-1β, and IL-6 in serum, significantly decrease the mRNA level of neural nitric oxide synthase (nNOS) in the cerebral cortex and hippocampus, and inhibit the nNOS protein level in the hippocampus. Concomitant measurements of the HPA axis upstream regulator corticotropin releasing factor (CRF) and its receptor CRFR found that AEO significantly decreases the gene expression of CRF, and significantly inhibits the gene transcription and protein expression of CRFR in the cerebral cortex and hippocampus. Additionally, AEO dose-dependently reduces the concentrations of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) downstream of the HPA axis, as measured by ELISA kits. These results together demonstrate that AEO exerts anxiolytic and antidepressant effects which are related to the inhibition of CRF and hyperactivity of the HPA axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.