ArticleMicromachines2017
An Electromagnetically Actuated Double-Sided Cell-Stretching Device for Mechanobiology Research.
Article in Micromachines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Stretchable Porous Membranes for Barrier Tissue Models with Real-Time Measurement and Biomimetic Cyclic Strain.Micromachines · 2025Article
- RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer.Advanced biology · 2025Article
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Cyclic stretch enhances neutrophil extracellular trap formation.BMC biology · 2024Article
- Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells.Microsystems & nanoengineering · 2024Article
- Uniaxial Cyclic Cell Stretching Device for Accelerating Cellular Studies.Micromachines · 2023Article
- Mechanical regulation of signal transduction in angiogenesis.Frontiers in cell and developmental biology · 2022Review
- The Integration of Optical Stimulation in a Mechanically Dynamic Cell Culture Substrate.Frontiers in bioengineering and biotechnology · 2022Article
- In Vitro Strategies to Vascularize 3D Physiologically Relevant Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.Biophysical reviews · 2021Review
- Remote-Controlled 3D Porous Magnetic Interface toward High-Throughput Dynamic 3D Cell Culture.ACS biomaterials science & engineering · 2021Article
- Bioscaffolds embedded with regulatory modules for cell growth and tissue formation: A review.Bioactive materials · 2021Review
- High-Throughput Magnetic Actuation Platform for Evaluating the Effect of Mechanical Force on 3D Tumor Microenvironment.Advanced functional materials · 2021Article
- Studying the Mechanobiology of Aortic Endothelial Cells Under Cyclic Stretch Using a Modular 3D Printed System.Frontiers in bioengineering and biotechnology · 2021Article
- Engineering liver microtissues for disease modeling and regenerative medicine.Advanced functional materials · 2020Article
- RhoA and Rac1 in Liver Cancer Cells: Induction of Overexpression Using Mechanical Stimulation.Micromachines · 2020Article
- Low-frequency flexural wave based microparticle manipulation.Lab on a chip · 2020Article
- New MEMS Tweezers for the Viscoelastic Characterization of Soft Materials at the Microscale.Micromachines · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular response to mechanical stimuli is an integral part of cell homeostasis. The interaction of the extracellular matrix with the mechanical stress plays an important role in cytoskeleton organisation and cell alignment. Insights from the response can be utilised to develop cell culture methods that achieve predefined cell patterns, which are critical for tissue remodelling and cell therapy. We report the working principle, design, simulation, and characterisation of a novel electromagnetic cell stretching platform based on the double-sided axial stretching approach. The device is capable of introducing a cyclic and static strain pattern on a cell culture. The platform was tested with fibroblasts. The experimental results are consistent with the previously reported cytoskeleton reorganisation and cell reorientation induced by strain. Our observations suggest that the cell orientation is highly influenced by external mechanical cues. Cells reorganise their cytoskeletons to avoid external strain and to maintain intact extracellular matrix arrangements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.